Carboxymethylation of kappa-carrageenan for intestinal-targeted delivery of bioactive macromolecules
Abstract
The work presented herein discusses the carboxymethylation of kappa-carrageenan, a natural linear polysaccharide, to afford a pH-dependent swelling property allowing for intestinal-targeted delivery of bioactive macromolecules. The carboxymethylation conditions with respect to the volume and concentration of sodium hydroxide (VNaOH, CNaOH), weight of monochloroacetic acid (WMCA), and reaction temperature (T) were optimized using a response...
Paper Details
Title
Carboxymethylation of kappa-carrageenan for intestinal-targeted delivery of bioactive macromolecules
Published Date
Feb 1, 2011
Journal
Volume
83
Issue
4
Pages
1507 - 1515
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