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Lip Yong Chung
University of Malaya
Organic chemistryChemistryIn vivoBiochemistryBiology
97Publications
19H-index
2,191Citations
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Publications 95
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Abstract Active targeting compound, a non-iodinated derivative of IK-IK-I2-azaBODIPY (1a) was previously reported to preferentially bind melanoma over healthy cells. In this study, we evaluate the photodynamic therapy (PDT) efficiency on melanoma cells of 1a, together with its reversed sequence compound KI-KI-I2-azaBODIPY (1b) and a non-targeted control I2-azaBODIPY-NH2 (2). All three test compounds possess absorption wavelengths in the near-infrared (NIR) region (λmax between 678 and 687 nm) wh...
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#1Theebaa Anasamy (UM: University of Malaya)H-Index: 5
#2Chin Fei Chee (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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Abstract This study reports the in vivo performance of two tribenzyltin carboxylate complexes, tri(4-fluorobenzyl)tin[(N,N-diisopropylcarbamothioyl)sulfanyl]acetate (C1) and tribenzyltin isonicotinate (C9), in their native form as well as in a poly(lactic-co-glycolic acid) (PLGA)-based nanoformulation, to assess their potential to be translated into clinically useful agents. In a 4T1 murine metastatic mammary tumour model, single intravenous administration of C1 (2.7 mg/kg) and C9 (2.1 mg/kg; 2....
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#1Pratyusa Sahoo (UM: University of Malaya)H-Index: 1
#2Kok Hoong Leong (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 6 authors...
Abstract We previously reported that insulin-entrapped chitosan complexed carboxymethylated iota-carrageenan (CS/CMCi) particles exhibit pH-responsive swelling behavior. However, the particles’ stability in the enzymatic gastrointestinal environment, their drug permeability mechanism, and related in vivo studies have not been discussed to date. In this study, we investigated the stability, muco-adhesiveness, transport mechanism and in vivo assessment of the particles. The particles retained thei...
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#1Nur ‘Afina Rusdi (Management and Science University)
#2Chin Siang Kue (Management and Science University)H-Index: 4
Last. Lik Voon Kiew (UM: University of Malaya)H-Index: 11
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Despite the extensive work on anticancer drug discovery, the number of potent lead compounds that enter the preclinical and clinical trials thus far is still low due to the poor selectivity and und...
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#1Hui Li Heng (UM: University of Malaya)H-Index: 1
#2Chin Fei Chee (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 11 authors...
1 CitationsSource
#1Laura Chambre (Boğaziçi University)H-Index: 2
#2Wen Shang SawH-Index: 3
Last. Amitav Sanyal (Boğaziçi University)H-Index: 25
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Photosensitizing nanogels were obtained through a surfactant-free single-step protocol by using a porphyrin-based cross-linker for stabilizing self-assembled nanosized aggregates of thermoresponsive copolymers. Nanogels with varying amounts of porphyrin retained the singlet oxygen generation ability of the porphyrin core and were also capable of inducing temperature increase upon irradiation at 635 nm. Photoinduced killing efficiency was tested against three cell lines: human breast adenocarcino...
1 CitationsSource
#1Chin Siang Kue (Management and Science University)H-Index: 4
#2Shie Yin Ng (UM: University of Malaya)H-Index: 2
Last. Hong Boon Lee (UM: University of Malaya)H-Index: 7
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BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region. Despite their extraordinary photophysical characteristics, they are not featured in clinical photodynamic therapy. This review discusses the recent advances in the design and/or modifications of BODIPYs since 2013, to improve their potential in photodynamic cancer therapy and related areas.
16 CitationsSource
#1Ampornphan Siriviriyanun (NTUST: National Taiwan University of Science and Technology)H-Index: 6
#2Ya-Ju Tsai (NTUST: National Taiwan University of Science and Technology)H-Index: 2
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 10 authors...
Abstract In this study, nanohybrid materials consisting of graphene oxide (GO), β‑cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) were successfully prepared by covalent bonding. GO-CD and GO-CD-DEN were found to be potential nanocarriers for anticancer drugs including chemotherapeutics (doxorubicin (DOX), camptothecin (CPT)) and photosensitizer (protoporphyrin IX (PpIX)). GO-CD possessed 1.2 times higher DOX-loading capacity than GO due to inclusion of additional DOX to the CD. The drug ...
6 CitationsSource
#1Hoay Yan CheahH-Index: 3
#2Elena GallonH-Index: 5
Last. Lik Voon KiewH-Index: 11
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We previously developed a new zinc(II) phthalocyanine (ZnPc) derivative (Pc 1) conjugated to poly-L-glutamic acid (PGA) (1-PG) to address the limitations of ZnPc as part of an antitumor photodynamic therapy approach, which include hydrophobicity, phototoxicity, and nonselectivity in biodistribution and tumor targeting. During this study, we discovered that 1-PG possessed high near-infrared (NIR) light absorptivity (λmax = 675 nm), good singlet oxygen generation efficiency in an aqueous environme...
2 CitationsSource
#1Hui Li Heng (UM: University of Malaya)H-Index: 1
#2Chin Fei Chee (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 11 authors...
Correction for ‘Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists’ by Hui Li Heng et al., Med. Chem. Commun., 2018, DOI: 10.1039/c7md00629b.
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