Original paper

Structural basis for activation of the complement system by component C4 cleavage

Volume: 109, Issue: 38, Pages: 15425 - 15430
Published: Sep 4, 2012
Abstract
An essential aspect of innate immunity is recognition of molecular patterns on the surface of pathogens or altered self through the lectin and classical pathways, two of the three well-established activation pathways of the complement system. This recognition causes activation of the MASP-2 or the C1s serine proteases followed by cleavage of the protein C4. Here we present the crystal structures of the 203-kDa human C4 and the 245-kDa C4·MASP-2...
Paper Details
Title
Structural basis for activation of the complement system by component C4 cleavage
Published Date
Sep 4, 2012
Volume
109
Issue
38
Pages
15425 - 15430
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