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Gregers R. Andersen
Aarhus University
Elongation factorMolecular biologyChemistryBiochemistryBiology
175Publications
36H-index
4,022Citations
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Publications 186
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#1Henrik Pedersen (AU: Aarhus University)H-Index: 25
#2Rasmus K. Jensen (AU: Aarhus University)H-Index: 5
Last. Gregers R. Andersen (AU: Aarhus University)H-Index: 36
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The complement system is a tightly controlled proteolytic cascade in the innate immune system, which tags intruding pathogens and dying host cells for clearance. An essential protein in this process is complement component C3. Uncontrolled complement activation has been implicated in several human diseases and disorders and has spurred the development of therapeutic approaches that modulate the complement system. Here, using purified proteins and several biochemical assays and surface plasmon re...
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#1Rasmus K. Jensen (AU: Aarhus University)H-Index: 5
#2Goran Bajic (Harvard University)H-Index: 10
Last. Gregers R. Andersen (AU: Aarhus University)H-Index: 36
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Complement receptor 3 (CR3, also known as Mac-1, integrin M2, or CD11b/CD18) is expressed on a subset of myeloid and certain activated lymphoid cells. CR3 is essential for the phagocytosis of complement-opsonized particles such as pathogens and apoptotic or necrotic cells. The receptor recognizes cells opsonized with the complement fragment iC3b and to a lesser extend C3dg. While the interaction between the iC3b thioester domain and the ligand binding CR3 M I-domain is now structurally well char...
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#1Gregers R. AndersenH-Index: 36
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#1Rasmus K. Jensen (AU: Aarhus University)H-Index: 5
#2Frederic Jabs (AU: Aarhus University)H-Index: 3
Last. Gregers R. Andersen (AU: Aarhus University)H-Index: 36
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BACKGROUND: IgE is the central antibody isotype in TH2-biased immunity and allergic diseases. The structure of intact IgE and the impact of IgE-targeting molecules on IgE however remain elusive. In order to obtain insights into IgE biology and the clinical impact, we aimed for structure determination of IgE and the complex of IgE with the anti-IgE antibody ligelizumab. METHODS: Structures of two distinct intact IgE with specificity for cross-reactive carbohydrate determinants and Der p 2 as well...
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#2Per Qvist (AU: Aarhus University)H-Index: 7
Last. Poul Henning JensenH-Index: 36
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Aggregation of alpha-synuclein (alphaSN) is an important histological feature of Parkinson disease. Recent studies showed that the release of misfolded alphaSN from human and rodent neurons is relevant to the progression and spread of alphaSN pathology. Little is known, however, about the mechanisms responsible for clearance of extracellular alphaSN. This study found that human complement receptor (CR) 4 selectively bound fibrillar alphaSN, but not monomeric species. alphaSN is an abundant prote...
1 CitationsSource
#2Gregers R. AndersenH-Index: 36
Last. Rasmus WilligH-Index: 5
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#1Dennis Pedersen (AU: Aarhus University)H-Index: 12
#2Trine Amalie Fogh Gadeberg (AU: Aarhus University)
Last. Gregers R. Andersen (AU: Aarhus University)H-Index: 36
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Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of convertase bound FP. A structural core formed by three thrombospondin repeats (TSRs) and a TB domain harbors the convertase binding site in FP that mainly interacts with C3b. Stabilization of the interaction between the C3b C-terminus and the MI...
2 CitationsSource
#2Dennis PedersenH-Index: 12
Last. Gregers R. AndersenH-Index: 36
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#2Gregers R. AndersenH-Index: 36
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#2Gregers R. AndersenH-Index: 36
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