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Rune T. Kidmose
Aarhus University
Complement systemMolecular biologyChemistryCrystallographyBiology
20Publications
6H-index
232Citations
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Publications 20
Newest
#1M.B.L. Winkler (AU: Aarhus University)H-Index: 1
#2Rune T. Kidmose (AU: Aarhus University)H-Index: 6
Last. Bjørn Panyella Pedersen (AU: Aarhus University)H-Index: 13
view all 8 authors...
Summary Niemann-Pick type C (NPC) proteins are essential for sterol homeostasis, believed to drive sterol integration into the lysosomal membrane before redistribution to other cellular membranes. Here, using a combination of crystallography, cryo-electron microscopy, and biochemical and in vivo studies on the Saccharomyces cerevisiae NPC system (NCR1 and NPC2), we present a framework for sterol membrane integration. Sterols are transferred between hydrophobic pockets of vacuolar NPC2 and membra...
4 CitationsSource
#1M.B.L. WinklerH-Index: 1
#2Rune T. KidmoseH-Index: 6
Last. Bjørn Panyella PedersenH-Index: 13
view all 3 authors...
Source
#1M.B.L. WinklerH-Index: 1
#2Rune T. KidmoseH-Index: 6
Last. Bjørn Panyella PedersenH-Index: 13
view all 3 authors...
Source
#1Rune T. Kidmose (AU: Aarhus University)H-Index: 6
#2Jonathan Juhl (AU: Aarhus University)H-Index: 2
Last. Bjørn Panyella Pedersen (AU: Aarhus University)H-Index: 13
view all 6 authors...
Model building into experimental maps is a key element of structural biology, but can be both time consuming and error prone for low-resolution maps. Here we present Namdinator, an easy-to-use tool that enables the user to run a molecular dynamics flexible fitting simulation followed by real-space refinement in an automated manner through a pipeline system. Namdinator will modify an atomic model to fit within cryo-EM or crystallography density maps, and can be used advantageously for both the in...
8 CitationsSource
#1Rune T. Kidmose (AU: Aarhus University)H-Index: 6
#2Gregers R. Andersen (AU: Aarhus University)H-Index: 36
Insulin is an essential regulator of glucose homeostasis. In this issue of Structure, Croll et al. (2016) reports a significantly improved model of the Fab-complexed IR ectodomain refined against a dataset extending to 3.3 A.
Source
#1Maja NielsenH-Index: 5
#2Rune T. KidmoseH-Index: 6
Last. Lasse JennerH-Index: 9
view all 3 authors...
Source
#1Maja NielsenH-Index: 5
#2Rune T. KidmoseH-Index: 6
Last. Lasse JennerH-Index: 9
view all 3 authors...
Source
#1Maja Nielsen (AU: Aarhus University)H-Index: 5
#2Rune T. Kidmose (AU: Aarhus University)H-Index: 6
Last. Lasse Jenner (AU: Aarhus University)H-Index: 9
view all 3 authors...
Saccharomyces cerevisiae TSA2 belongs to the family of typical 2-Cys peroxiredoxins, a ubiquitously expressed family of redox-active enzymes that utilize a conserved peroxidatic cysteine to reduce peroxides. Typical 2-Cys peroxiredoxins have been shown to be involved in protection against oxidative stress and in hydrogen peroxide signalling. Furthermore, several 2-Cys peroxiredoxins, including S. cerevisiae TSA1 and TSA2, are able to switch to chaperone activity upon hyperoxidation of their pero...
5 CitationsSource
#1Sofia Mortensen (AU: Aarhus University)H-Index: 3
#2Rune T. Kidmose (AU: Aarhus University)H-Index: 6
Last. Gregers R. Andersen (AU: Aarhus University)H-Index: 36
view all 6 authors...
Complement component C4 is a central protein in the classical and lectin pathways within the complement system. During activation of complement, its major fragment C4b becomes covalently attached to the surface of pathogens and altered self-tissue, where it acts as an opsonin marking the surface for removal. Moreover, C4b provides a platform for assembly of the proteolytically active convertases that mediate downstream complement activation by cleavage of C3 and C5. In this article, we present t...
27 CitationsSource
#1Sofia MortensenH-Index: 3
#2Rune T. KidmoseH-Index: 6
Last. Gregers R. AndersenH-Index: 36
view all 5 authors...
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