MBL2 Gene polymorphisms protect against development of thrombocytopenia associated with severe dengue phenotype

Dengue disease can clinically evolve from an asymptomatic and mild disease, known as dengue fever (DF), to a severe disease known as dengue hemorrhagic fever (DHF). Recent evidence has shown how host genetic factors can be correlated with severe dengue susceptibility or protection. Many of these genes, such as CD209, TNF-a, vitamin D receptor, and FCγ receptor IIA, are components of the innate immune system, suggesting that innate responses...