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Human Immunology
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#1Enrico Fainardi (UniFI: University of Florence)H-Index: 22
#2Daria Bortolotti (University of Ferrara)H-Index: 11
Last. Roberta Rizzo (University of Ferrara)H-Index: 29
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Abstract The aim of this study was to investigate the potential role of soluble Human Leukocyte Antigen-G (sHLA-G) molecules as biomarkers predicting outcome in acute ischemic stroke (AIS). Serum levels of total sHLA-G (sHLA-G1/HLA-G5) and its soluble isoforms sHLA-G1 and HLA-G5/G6 were measured by enzyme-linked immunosorbent assay (ELISA) in 92 AIS patients and healthy donors (HD). Incidence of hemorrhagic transformation (HT), size of final infarct volume (FIV) and clinical outcome at 3 months ...
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#1Simone Negrini (UniGe: University of Genoa)H-Index: 19
#2Paola Contini (UniGe: University of Genoa)H-Index: 25
Last. Francesco Puppo (UniGe: University of Genoa)H-Index: 37
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Abstract Human leucocyte antigen-G (HLA-G) is a nonclassical class I major histocompatibility complex (MHC) molecule characterized by complex immunoregulatory and tolerogenic functions. Membrane-bound HLA-G is expressed on the surface of different cell populations in both physiological and pathological conditions. Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by widespread tissue fibrosis, vascular lesions and immunological alterations. Systemic lupus erythematosus i...
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#1Daria Bortolotti (University of Ferrara)H-Index: 11
#2Emanuela Vitali (University of Ferrara)
Last. Piera Boschetto (University of Ferrara)H-Index: 31
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Abstract Heart failure (HF) is a syndrome caused by structural and/or functional cardiac abnormalities, resulting in a reduced cardiac output and/or elevated intracardiac pressures. Several studies reported a crucial role of immune activation and inflammation in the chronic heart failure (HF) pathogenesis, suggesting that pro-inflammatory and anti-inflammatory mediators could be predictive markers of the HF development and/or progression. Human Leukocyte Antigen-G (HLA-G), a tolerogenic and anti...
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#1Daria Bortolotti (University of Ferrara)H-Index: 11
#2Valentina Gentili (University of Ferrara)H-Index: 9
Last. Roberta Rizzo (University of Ferrara)H-Index: 29
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Abstract Infection is still a leading cause of death during the first year after heart transplantation. We evaluated the pre-transplant levels of HLA (Human Leukocyte antigen) – G molecules as a means of identifying heart recipients at risk of serious infections. We prospectively analyzed 122 adult heart transplant (HT) recipients. Serum samples were collected before transplantation and analyzed for sHLA-G levels by ELISA assay. The clinical follow-up period lasted 5 years. Clinical outcomes wer...
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#1Hiroshi Watanabe (Hokkaido University)H-Index: 7
#2Kimiko Kuroki (Hokkaido University)H-Index: 12
Last. Katsumi Maenaka (Hokkaido University)H-Index: 35
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Abstract Human leukocyte antigen (HLA)-G, a non-classical HLA class I molecule, has one of the splicing isoforms, HLA-G2, which lacks one domain (α2) and forms a non-covalent homodimer. HLA-G2 is expressed on placental cells, regulatory T cells, tumor cells, and virus-infected cells, and is involved in immunosuppression. The major isoform of HLA-G, HLA-G1, binds to leukocyte immunoglobulin (Ig)-like receptor (LILR) B1 and LILRB2, on the contrary, HLA-G2 binds to only LILRB2. We previously report...
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#1Gry Persson (UCPH: University of Copenhagen)H-Index: 4
#2Nanna K. Jorgensen (UCPH: University of Copenhagen)H-Index: 17
Last. Thomas Vauvert F. Hviid (UCPH: University of Copenhagen)H-Index: 10
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Abstract The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune modulation and during pregnancy, and also possible implications in a range of diseases, in infertility and pregnancy complications, HLA-F has nearly been ignored. However, re...
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#1Hana RohnH-Index: 2
#2Esther SchwichH-Index: 2
Last. Vera RebmannH-Index: 32
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Abstract The immunosuppressive non-classical human leukocyte antigen-G (HLA-G) promotes transplant tolerance as well as viral immune escape. HLA-G expression is associated with regulatory elements targeting certain single nucleotide polymorphisms (SNPs) in the HLA-G 3′ untranslated region (UTR). Thus, we evaluated the impact of HLA-G 3′UTR polymorphisms as surrogate markers for BK polyomavirus (BKPyV) replication or nephropathy (PyVAN) and acute cellular and antibody mediated rejection (ACR/AMR)...
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#1Marzieh Mansouri (Shiraz University of Medical Sciences)
Last. Shirin Farjadian (Shiraz University of Medical Sciences)H-Index: 19
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Abstract In addition to T cells, NK cells can also participate in the outcome of hematopoietic stem cell transplantation (HSCT) mainly through the interaction between donor killer cell immunoglobulin-like receptors (KIRs) and recipient human leukocyte antigen (HLA) class I molecules. There is a risk of GVHD other than leukemia relapse after allogeneic HSCT that activation of donor NK cells in the absence of appropriate inhibitory ligands will be one of the reasons. To investigate the impact of d...
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#1Kelly Jean IngramH-Index: 1
Last. Michael D. GautreauxH-Index: 14
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#1Rebecca Pavlos (UWA: University of Western Australia)H-Index: 10
#2Pooja Deshpande (UWA: University of Western Australia)H-Index: 4
Last. D Dunn (UWA: University of Western Australia)
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Abstract Abacavir hypersensitivity syndrome (ABC HSS) is strongly associated with carriage of human leukocyte antigen (HLA)-B*57:01, which has a 100% negative predictive value for the development of ABC HSS. However, 45% of individuals who carry HLA-B*57:01 can tolerate ABC. We investigated immune and non-immune related genes in ABC HSS (n = 95) and ABC tolerant (n = 43) HLA-B*57:01 + patients to determine other factors required for the development of ABC HSS. Assignment of phenotype showed that...
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Human leukocyte antigen
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