Bartolomeu Acioli-Santos
Oswaldo Cruz Foundation
GenotypeDengue virusDengue feverGeneticsBiology
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Publications 10
#2Cristiane C. Bresani-Salvi (FIOCRUZ: Oswaldo Cruz Foundation)
Last. Bartolomeu Acioli-Santos (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 5
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There are few data considering human genetics as an important risk factor for birth abnormalities related to ZIKV infection during pregnancy, even though sub-Saharan African populations are apparently more resistant to CZS as compared to populations in the Americas. We hypothesized that single nucleotide variants (SNVs), especially in innate immune genes, could make some populations more susceptible to Zika congenital complications than others. Differences in the SNV frequencies among continenta...
#1Carolline Araújo-Mariz (UFPE: Federal University of Pernambuco)H-Index: 1
#2Maria de Fátima (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 16
Last. Bartolomeu Acioli-SantosH-Index: 1
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Hepatotoxicity during tuberculosis (TB) treatment is frequent and may be related to the Arylamine N-Acetyltransferase (NAT2) acetylator profile, in which allele frequencies differ according to the population. The aim of this study was to investigate functional polymorphisms in NAT2 associated with the development of hepatotoxicity after initiating treatment for TB in people living with HIV/AIDS (PLWHA) in Pernambuco, Northeast Brazil.
Last. Bartolomeu Acioli-Santos (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 5
view all 9 authors...
Dengue has become one of the most important worldwide arthropodborne diseases around the world. Here, one hundred and two Brazilian dengue virus (DENV) III patients and controls were genotyped for 322 innate immunity gene loci. All biological data (including age, sex and genome background) were analyzed using Machine Learning techniques to discriminate tendency to severe dengue phenotype development. Our current approach produces median values for accuracy greater than 86%, with sensitivity and ...
1 CitationsSource
#1Beatriz Peixoto Azevedo (UFPE: Federal University of Pernambuco)
#1AzevedoBeatriz Peixoto (UFPE: Federal University of Pernambuco)
Last. Acioli-SantosBartolomeu (FIOCRUZ: Oswaldo Cruz Foundation)
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#1Caio César Medeiros Davi (A&M: Texas A&M University)H-Index: 2
Last. Bartolomeu Acioli-SantosH-Index: 5
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Dengue has become one of the most important worldwide arthropod-borne diseases. Dengue phenotypes are based on laboratorial and clinical exams, which are known to be inaccurate. Objective : We present a machine learning approach for the prediction of dengue fever severity based solely on human genome data. Methods : One hundred and two Brazilian dengue patients and controls were genotyped for 322 innate immunity single nucleotide polymorphisms (SNPs). Our model uses a support vector machine algo...
1 CitationsSource
Hepatotoxicity is frequently reported as an adverse reaction during the treatment of tuberculosis. The aim of this study was to determine the incidence of hepatotoxicity and to identify predictive factors for developing hepatotoxicity after people living with HIV/AIDS (PLWHA) start treatment for tuberculosis. This was a prospective cohort study with PLWHA who were monitored during the first 60 days of tuberculosis treatment in Pernambuco, Brazil. Hepatotoxicity was considered increased levels of...
5 CitationsSource
#1André Filipe Pastor (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 2
#2Laís Rodrigues Moura (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 1
Last. Bartolomeu Acioli-Santos (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 5
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Abstract Four genetic polymorphisms located at the promoter (C-257T) and coding regions of CFH gene (exon 2 G257A, exon 14 A2089G and exon 19 G2881T) were investigated in 121 dengue patients (DENV-3) in order to assess the relationship between allele/haplotypes variants and clinical outcomes. A statistical value was found between the CFH-257T allele (TT/TC genotypes) and reduced susceptibility to severe dengue (SD). Statistical associations indicate that individuals bearing a T allele presented ...
9 CitationsSource
The Pisolithus tinctorius symbiosis related protein expressed sequence tag (EST PtSRP) was previously identified in the first hours of the interaction between the fungus Pisolithus tinctorius and sweet chestnut Castanea sativa, and partially characterized as a fungal marker gene of ectomycorrhizal symbiosis formation. We used the 5’ rapid amplification of cDNA ends (RACE) to obtain the PtSRP mRNA 5’ region, and together with our previously reported 3’ mRNA region, the full mRNA sequence was asse...
1 CitationsSource
#1Carlos E. Calzavara-Silva (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 7
#2Ana L. Gomes (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 11
Last. Ernesto T. A. Marques (Johns Hopkins University)H-Index: 32
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The management of acute dengue patients during outbreaks is a challenging problem. Most of the dengue fever cases are benign, but some cases develop into a severe and possibly lethal vasculopathy, known as dengue hemorrhagic fever. Early symptoms of dengue and hemorrhagic fever are very similar. An early differential diagnosis is needed to predict which of these two clinical presentations is crucial to proper patient care and public health management. This study evaluates the predictive potentia...
7 CitationsSource
#1Bartolomeu Acioli-Santos (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 5
#2Ludovica Segat (UniTS: University of Trieste)H-Index: 20
Last. Sergio Crovella (UFPE: Federal University of Pernambuco)H-Index: 30
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Dengue disease can clinically evolve from an asymptomatic and mild disease, known as dengue fever (DF), to a severe disease known as dengue hemorrhagic fever (DHF). Recent evidence has shown how host genetic factors can be correlated with severe dengue susceptibility or protection. Many of these genes, such as CD209, TNF-a, vitamin D receptor, and FCγ receptor IIA, are components of the innate immune system, suggesting that innate responses might have a role in dengue pathogenesis. MBL2 gene pol...
43 CitationsSource