Epigenetic Regulation of Monoallelic Rearrangement (Allelic Exclusion) of Antigen Receptor Genes
Abstract
While most genes in the mammalian genome are transcribed from both parental chromosomes in cells where they are expressed, approximately 10% of genes are expressed monoallelically, so that any given cell will express either the paternal or maternal allele, but not both. The antigen receptor genes in B and T cells are well studied examples of a gene family which is expressed in a monoallelic manner, in a process coined "allelic exclusion". During...
Paper Details
Title
Epigenetic Regulation of Monoallelic Rearrangement (Allelic Exclusion) of Antigen Receptor Genes
Published Date
Dec 5, 2014
Journal
Volume
5
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