Frontiers in Immunology
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#1Joseph G. Skeate (SC: University of Southern California)H-Index: 7
#2Mikk E. Otsmaa (SC: University of Southern California)
Last. W. Martin Kast (SC: University of Southern California)H-Index: 62
view all 6 authors...
Tumor necrosis factor superfamily member 14 (LIGHT) has been in pre-clinical development for over a decade and shows promise as a modality of enhancing treatment approaches in the field of cancer immunotherapy. To date, LIGHT has been used to combat cancer in multiple tumor models where it can be combined with other immunotherapy modalities to clear established solid tumors as well as treat metastatic events. When LIGHT molecules are delivered to or expressed within tumors they cause significant...
#1Lotus L. van den Hoogen (Tulane University)
#2Gillian Stresman (Lond: University of London)H-Index: 12
Last. Thomas Druetz (UdeM: Université de Montréal)H-Index: 8
view all 20 authors...
In our aim to eliminate malaria, more sensitive tools to detect residual transmission are quickly becoming essential. Antimalarial antibody responses persist in the blood after a malaria infection and provide a wider window to detect exposure to infection compared to parasite detection metrics. Here, we aimed to select antibody responses associated with recent and cumulative exposure to malaria using cross-sectional survey data from Haiti, an elimination setting. Using a multiplex bead assay, we...
#1Jing Zhang (Anhui Medical University)
#2Xiao-Xi Hu (Anhui Medical University)
Last. Wei Wei (Anhui Medical University)H-Index: 57
view all 8 authors...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and T cell hyper-activation. Emerging evidence has shown that the stimulation of immunoglobulin D (IgD) induces T cell activation and may contribute to diseases pathogenesis. In this study, the sIgD concentrations were positively associated with disease activity score in 28 joints (DAS28) and anti-cyclic citrullinated peptide (anti-CCP) in RA. We demonstrated that IgD-Fc-Ig (composed of human IgD Fc domain a...
#1Farha Naz (Jamia Millia Islamia)H-Index: 9
#2Mohd Arish (Jamia Hamdard)H-Index: 5
With the sudden outbreak of COVID-19 patient worldwide and associated mortality, it is critical to come up with an effective treatment against SARS-CoV-2. Studies suggest that mortality due to COVID 19 is mainly attributed to the hyper inflammatory response leading to cytokine storm and ARDS in infected patients. . Sphingosine-1-phosphate receptor 1 (S1PR1) analogs, AAL-R and RP-002, have earlier provided in-vivo protection from the pathophysiological response during H1N1 influenza infection and...
#1Marta Wieczorek (Humboldt University of Berlin)
#2Elena Ioana Braicu (Humboldt University of Berlin)H-Index: 16
Last. Véronique Blanchard (Humboldt University of Berlin)H-Index: 1
view all 5 authors...
Epithelial ovarian cancer (EOC) was previously shown to be associated with glycosylation changes of total serum and total IgG proteins. However, as a majority of previous studies analyzed released glycan profiles, still little is known about IgG subclass-specific alterations in ovarian cancer. Hence, in this study we investigated EOC-related glycosylation changes of the three most abundant IgG subclasses, namely IgG1, IgG2 and IgG3 isolated from sera of 87 EOC patients and 74 age-matched healthy...
#1Mariagrazia Lorenzin (UNIPD: University of Padua)H-Index: 9
#2Augusta Ortolan (UNIPD: University of Padua)H-Index: 8
Last. Roberta Ramonda (UNIPD: University of Padua)H-Index: 26
view all 10 authors...
Objectives:Our study aimed to identify: 1) the prevalence of spine and pelvis magnetic resonance imaging (MRI-spine and MRI-SIJ) inflammatory and structural lesions in patients (pts) with a diagnosis of axial spondyloarthritis (axSpA); 2) the predictive factors for a severe disease pattern with a higher probability of radiographic progression. Materials and Methods:Seventy-five pts with low back pain (LBP) (≥3 months, ≤2 years, onset ≤45 years) underwent physical examination, questionnaires, lab...
#1Francesco Pecora (Boston Children's Hospital)
#2Federica Persico (Boston Children's Hospital)
Last. Susanna Esposito (Boston Children's Hospital)H-Index: 50
view all 7 authors...
Celiac disease (CD) is an immune-mediated disorder initiated by the ingestion of gluten in genetically predisposed individuals. Recent data shows that changes in the gut microbiome composition and function are linked with chronic inflammatory diseases; this might also be the case for CD. The main aim of this manuscript is to discuss our present knowledge of the relationships between gut microbiota alterations and CD and to understand if there is any role for probiotics in CD therapy. PubMed was ...
#1Stefanie Marx (Saarland University)H-Index: 2
#2Claudia Adam (Saarland University)
Last. Martina Sester (Saarland University)H-Index: 37
view all 6 authors...
Dosage of immunosuppressive drugs after transplantation critically determines rejection and infection episodes. In this study, a global immune function assay was characterized among controls, dialysis-patients, and transplant-recipients to evaluate its utility for pharmacodynamic monitoring of immunosuppressive drugs and for predicting infections. Whole-blood samples were stimulated with anti-CD3/toll-like-receptor (TLR7/8)-agonist in the presence or absence of drugs and IFN-γ secretion was meas...
#1Albert Zlotnik (UCI: University of California, Irvine)H-Index: 69
#1Alireza Labani-Motlagh (Uppsala University)
#2Mehrnoush Ashja-Mahdavi (Umeå University)
Last. Angelica Loskog (Uppsala University)H-Index: 28
view all 3 authors...
The success of cancer immunotherapy relies on the knowledge of the tumor microenvironment and the immune evasion mechanisms in which the tumor, stroma and infiltrating immune cells function in a complex network. The potential barriers that profoundly challenge the overall clinical outcome of promising therapies need to be fully identified and counteracted. Although cancer immunotherapy has increasingly been applied, we are far from understanding how to utilize different strategies in the best wa...
Top fields of study
T cell
Immune system