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Frontiers in Immunology
IF
4.72
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10628
Papers 11564
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Published on Jan 1, 2019in Frontiers in Immunology 4.72
David DeWolfe (UR: University of Rochester), Malika Aid6
Estimated H-index: 6
(BIDMC: Beth Israel Deaconess Medical Center)
+ 7 AuthorsChen S. Tan10
Estimated H-index: 10
(BIDMC: Beth Israel Deaconess Medical Center)
Background: A previously proposed immune risk profile (IRP), based on T cell phenotype and CMV serotype, is associated with mortality in the elderly and increased infections post-kidney transplant. To evaluate if NK cells contribute to the IRP and if the IRP can be predicted by a clinical T cell functional assays, we conducted a cross sectional study in renal transplant candidates to determine the incidence of IRP and its association with sepcificNK cell characteristics and ImmuKnow® value. Mate...
Published in Frontiers in Immunology 4.72
Takashi Fujimura (Hiroshima University), Shelly Zing Chin Lum (Boston Children's Hospital)+ -3 AuthorsMichiko K. Oyoshi20
Estimated H-index: 20
(Harvard University)
The prevalence of food allergy has been steadily rising worldwide with the highest incidence noted among younger children, and increasingly recognized as a growing public concern. Allergic reactions to foods often occur on the first known ingestion, suggesting that exposure of offspring to food allergens may occur in utero and/or through breast milk. This creates a milieu that shapes the neonatal immune response to these allergens. However, the effects of maternal allergen exposure and maternal ...
Published in Frontiers in Immunology 4.72
Xin-Cang Li9
Estimated H-index: 9
(Chinese Academy of Fishery Sciences),
Jian Zhou (Chinese Academy of Fishery Sciences)+ -3 AuthorsWenhong Fang10
Estimated H-index: 10
(Chinese Academy of Fishery Sciences)
Scavenger receptors are cell surface membrane-bound receptors that typically bind multiple ligands and promote the removal of endogenous proteins and pathogens. In this study, we characterized a novel scavenger receptor-like protein, namely, SpBark. SpBark was upregulated in hemocytes after challenges with bacteria, suggesting that it might be involved in antibacterial defense. SpBark is a type I transmembrane protein with four extracellular domains, including three scavenger receptor cysteine-r...
Published in Frontiers in Immunology 4.72
Thomas Renné39
Estimated H-index: 39
(UHH: University of Hamburg),
Evi X. Stavrou13
Estimated H-index: 13
(Case Western Reserve University)
Factor XII (FXII) is the zymogen of serine protease, factor XIIa (FXIIa). FXIIa enzymatic activities have been extensively studied and FXIIa inhibition is emerging as a promising target to treat or prevent thrombosis without creating a hemostatic defect. FXII and plasma prekallikrein reciprocally activate each other and result in liberation of bradykinin. Due to its unique structure among coagulation factors, FXII exerts mitogenic activity in endothelial and smooth muscle cells, indicating that ...
Published in Frontiers in Immunology 4.72
Tim Willinger14
Estimated H-index: 14
(KI: Karolinska Institutet)
Innate lymphoid cells (ILCs) are specialized immune cells that rapidly respond to environmental challenges, such as infection and tissue damage. ILCs play an important role in organ homeostasis, tissue repair, and host defense in the mucosal tissues intestine and lung. ILCs are sentinels of healthy tissue function, yet it is poorly understood how ILCs are recruited, strategically positioned, and maintained within tissues. Accordingly, ILC migration is an area that has recently come into focus an...
Published in Frontiers in Immunology 4.72
Toru Kato2
Estimated H-index: 2
(Hyogo College of Medicine),
Koubun Yasuda18
Estimated H-index: 18
(Hyogo College of Medicine)
+ -3 AuthorsHiroaki Shibahara (Hyogo College of Medicine)
Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6% to 10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be used for patients wishing to become pregnant. Despite the high morbidity, the pathogenesis of endometriosis has not been well elucidated. Several inflammatory cytokines are repo...
Published in Frontiers in Immunology 4.72
Ming Jiang (SYSU: Sun Yat-sen University), Zhuang-gui Chen1
Estimated H-index: 1
(SYSU: Sun Yat-sen University)
+ -3 AuthorsBo Peng14
Estimated H-index: 14
(SYSU: Sun Yat-sen University)
Temperature is one of the major climate factors that affects the outbreak of infectious disease. Lines of evidences have shown that virulence factors can be controlled by thermo-sensors in bacterial pathogens. However, how temperature influence host’s responses to the pathogen is still largely unexplored, and the study on which might pave the way to develop strategies to manage pathogenic bacterial infection. In the present study, we show that finfish Carassius carassius, the crucian carp that i...
Published in Frontiers in Immunology 4.72
Asaf Maoz (BU: Boston University), Michael Dennis (BU: Boston University), Joel K. Greenson61
Estimated H-index: 61
(UM: University of Michigan)
The Crohn’s-like lymphoid reaction (CLR) to colorectal cancer (CRC), a CRC-specific ectopic lymphoid reaction, is thought to play an important role in the host response to CRC. CLR is characterized by peritumoral lymphocytic aggregates that are found at the advancing edge of the tumor. Spatial and molecular characterization of CLR within the tumor microenvironment (TME) have uncovered a spectrum of peritumoral lymphoid aggregates with varying levels of organization and maturation. In early stage...
Published in Frontiers in Immunology 4.72
Rafijul Bari6
Estimated H-index: 6
,
Markus Granzin4
Estimated H-index: 4
(Miltenyi Biotec)
+ -3 AuthorsWing Leung2
Estimated H-index: 2
(Miltenyi Biotec)
Genetic engineering is an important tool for redirecting the function of various types of immune cells and their use for therapeutic purpose. Although NK cells have many beneficial therapeutic features, genetic engineering of immune cells for targeted therapy focuses mostly on T cells. One of the major obstacles for NK cell immunotherapy is the lack of an efficient method for gene transfer. Lentiviral vectors have been proven to be a safe tool for genetic engineering, however lentiviral transduc...
Published in Frontiers in Immunology 4.72
Dennis Pedersen12
Estimated H-index: 12
(AU: Aarhus University),
Trine A.F. Gadeberg1
Estimated H-index: 1
(AU: Aarhus University)
+ -3 AuthorsSteen V. Petersen22
Estimated H-index: 22
(AU: Aarhus University)
Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of convertase bound FP. A structural core formed by three thrombospondin repeats (TSRs) and a TB domain harbors the convertase binding site in FP that mainly interacts with C3b. Stabilization of the interaction between the C3b C-terminus and the MI...
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