Original paper
Targeted PDT Agent Eradicates TrkC Expressing Tumors via Photodynamic Therapy (PDT)
Abstract
This contribution features a small molecule that binds TrkC (tropomyosin receptor kinase C) receptor that tends to be overexpressed in metastatic breast cancer cells but not in other breast cancer cells. A sensitizer for 1O2 production conjugated to this structure gives 1-PDT for photodynamic therapy. Isomeric 2-PDT does not bind TrkC and was used as a control throughout; similarly, TrkC– cancer cells were used to calibrate enhanced killing of...
Paper Details
Title
Targeted PDT Agent Eradicates TrkC Expressing Tumors via Photodynamic Therapy (PDT)
Published Date
Dec 9, 2014
Journal
Volume
12
Issue
1
Pages
212 - 222
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Notes
History