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Anyanee Kamkaew
University of Wisconsin-Madison
CancerInorganic chemistryChemistryIn vivoPhotodynamic therapy
28Publications
13H-index
1,364Citations
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Publications 27
Newest
#1Anyanee Kamkaew (Suranaree University of Technology)H-Index: 13
#2Feng Li (Houston Methodist Hospital)H-Index: 1
Last. Kevin Burgess (A&M: Texas A&M University)H-Index: 60
view all 4 authors...
Tropomyosin receptor kinases receptor C is expressed at high levels on the surface of tumors from metastatic breast cancer, metastatic melanoma, glioblastoma, and neuroblastoma. Previous studies have shown synthetic TrkC ligands bearing agents for photodynamic therapy could be used to completely ablate 4T1 metastatic breast tumors and suppress metastatic spread in vivo. Modification of these probes (A in the text) to make them suitable for near infrared optical imaging in vivo would require a su...
1 CitationsSource
#1Liang Cheng (Soochow University (Suzhou))H-Index: 92
#2Dawei Jiang (UW: University of Wisconsin-Madison)H-Index: 13
Last. Weibo Cai (UW: University of Wisconsin-Madison)H-Index: 64
view all 11 authors...
Nanomaterials with renal clearance from the body within a reasonable timescale have shown great promises in the area of nanomedicine recently. However, the integration of theranostic and renal clearance properties into a single ultrasmall nanostructure remains a great challenge. Herein, meso-tetra(4-carboxyphenyl)porphyrin (TCPP) structure is utilized as a model, for the first time using noninvasive dynamic positron emission tomography (PET) imaging to investigate the balance of the renal cleara...
29 CitationsSource
#1Anyanee KamkaewH-Index: 13
#2Nanyan FuH-Index: 1
Last. Kevin BurgessH-Index: 60
view all 4 authors...
Actively targeting probe 1b, an unsymmetrical bivalent dipeptide mimic, selectively bound melanoma over healthy skin tissue in histological samples from patients and Sinclair swine. Modifications to 1b gave agents 2–4 that contain a near-IR aza-BODIPY fluor. Contrary to our expectations, symmetrical probe 3 gave the highest melanoma-to-healthy skin selectivity in histochemistry and experiments with live cells; this was surprising because 2, not 3, is unsymmetrical like the original lead 1. Optic...
3 CitationsSource
#1Chin Siang KueH-Index: 4
#2Anyanee KamkaewH-Index: 13
Last. Hong Boon LeeH-Index: 10
view all 7 authors...
Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy
6 CitationsSource
#1Liang Cheng (Soochow University (Suzhou))H-Index: 92
#2Anyanee Kamkaew (UW: University of Wisconsin-Madison)H-Index: 13
Last. Weibo CaiH-Index: 64
view all 12 authors...
While position emission tomography (PET) is an important molecular imaging technique for both preclinical research and clinical disease diagnosis/prognosis, chelator-free radiolabeling has emerged as a promising alternative approach to label biomolecules or nanoprobes in a facile way. Herein, starting from bottom-up synthesized WS2 nanoflakes, this study fabricates a unique type of WS2/WOx nanodots, which can function as inherent hard oxygen donor for stable radiolabeling with Zirconium-89 isoto...
17 CitationsSource
#1Anyanee KamkaewH-Index: 13
#2Liang ChengH-Index: 92
Last. Weibo CaiH-Index: 64
view all 7 authors...
Traditional photodynamic therapy (PDT) requires external light to activate photosensitizers for therapeutic purposes. However, the limited tissue penetration of light is still a major challenge for this method. To overcome this limitation, we report an optimized system that uses Cerenkov radiation for PDT by using radionuclides to activate a well-known photosensitizer (chlorin e6, Ce6). By taking advantage of hollow mesoporous silica nanoparticles (HMSNs) that can intrinsically radiolabel an oxo...
27 CitationsSource
#1Liang ChengH-Index: 92
#2Anyanee KamkaewH-Index: 13
Last. Weibo CaiH-Index: 64
view all 10 authors...
Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise in nanomedicine. Herein, we develop an organic photodynamic therapy (PDT) system based on polyethylene glycol (PEG)-coated nanomicelles conjugated with ∼20% chlorin e6 (PEG-Ce 6 nanomicelles), which functions as an optical imaging agent, as well as a PDT agent. The formed PEG-Ce 6 nanomicelles with the size of ∼20 nm were highly stable in various physiological solutions for a long time. Moreover, ...
40 CitationsSource
#1Siew Hui VoonH-Index: 6
#2Shu Xian TiewH-Index: 2
Last. Lip Yong ChungH-Index: 19
view all 9 authors...
13 CitationsSource
#1Haiyan Sun (UW: University of Wisconsin-Madison)H-Index: 11
#2Christopher G. England (UW: University of Wisconsin-Madison)H-Index: 19
Last. Weibo Cai (UW: University of Wisconsin-Madison)H-Index: 64
view all 10 authors...
Purpose Overexpression of CD146 in solid tumors has been linked to disease progression, invasion, and metastasis. We describe the generation of a 64Cu-labeled CD146-specific antibody and its use for quantitative immunoPET imaging of CD146 expression in six lung cancer models.
11 CitationsSource
#1Christopher G. England (UW: University of Wisconsin-Madison)H-Index: 19
#2Anyanee Kamkaew (UW: University of Wisconsin-Madison)H-Index: 13
Last. Weibo Cai (UW: University of Wisconsin-Madison)H-Index: 64
view all 11 authors...
The role of insulin-like growth factor-1 receptor (IGF-1R) in cancer tumorigenesis was established decades ago, yet there are limited studies evaluating the imaging and therapeutic properties of anti-IGF-1R antibodies. Noninvasive imaging of IGF-1R may allow for optimized patient stratification and monitoring of therapeutic response in patients. Herein, this study reports the development of a Zirconium-89 (89Zr)-labeled anti-IGF-1R antibody (89Zr-Df-1A2G11) for PET imaging of pancreatic cancer. ...
8 CitationsSource
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