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Molecular Pharmaceutics
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#1Ozge ErH-Index: 7
#2Ayça TunçelH-Index: 2
Last. Fatma YurtH-Index: 6
view all 8 authors...
Photodynamic therapy (PDT) is a non-invasive therapy based on the photodynamic effect. In this study, we sought to determine intracellular uptake and in vivo photodynamic therapy potential of Zn ph...
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Recent cancer immunotherapy has attracted much attention due to high specificity and recurrence prevention of tumor. Nevertheless, its therapeutic effects are still challenging in solid cancer. To ...
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Presence of cancer stem cells (CSCs) in tumor micro environment is responsible for development of chemo-resistance and recurrence of cancer. Our previous investigation revealed the anti-cancer mech...
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#1Xingyu LuH-Index: 13
#2Mingyue LiH-Index: 5
Last. Yongchao SuShenhuiH-Index: 23
view all 9 authors...
Despite the wide utilization of amorphous solid dispersions (ASDs) for formulating poorly water-soluble drugs, fundamental understanding of the structural basis behind their stability and dissoluti...
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Determining the temperature at which the thermal unfolding of a protein starts becoming irreversible is relevant for many areas of protein research. Until now, published methods cannot determine, w...
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#1Danfeng WeiH-Index: 1
#2Ze TaoH-Index: 3
Last. Sheng-FuLiH-Index: 17
view all 12 authors...
Antibody-based near-infrared photoimmunotherapy (NIR-PIT) is an attractive strategy for cancer treatment. Tumor cells can be selectively and efficiently killed by the targeted delivery of an antibo...
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#1Zhiyuan Sun (NKU: Nankai University)H-Index: 1
#2Haoqi Zhang (NKU: Nankai University)
Last. Xinglu Huang (NKU: Nankai University)H-Index: 1
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Reports on the comprehensive factors for design considerations of hypoxia-activated prodrugs (HAPs) are rare. We introduced a new model system composed of a series of highly water-soluble HAPs, pro...
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Optimized physical properties (e.g. bulk, surface/interfacial and mechanical properties) of active pharmaceutical ingredients (APIs) are key to the successful integration of drug substance and drug product manufacturing, robust drug product manufacturing operations, and ultimately to attaining consistent drug product critical quality attributes. However, an appreciable number of APIs have physical properties that cannot be managed via routes such as form selection, adjustments to the crystalliza...
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Understanding cellular uptake mechanisms of nanoparticles with therapeutic potential has become critical in the field of drug delivery. Elucidation of cellular entry routes can aid in the dissectio...
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#1Mingyue LiH-Index: 5
Last. Yongchao SuShenhuiH-Index: 23
view all 8 authors...
In solid dosage formulations, probing intermolecular interactions between active pharmaceutical ingredients (APIs) and polymeric excipients, which have mechanistic impact on physical stability as well as bioavailability, remains a challenge. In recent years, solid-state NMR spectroscopy has been demonstrated to be a powerful tool to provide structural details with atomic resolution of therapeutic organic compounds and formulation products. However, conventional 13C-detected techniques often suff...
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Top fields of study
Molecular biology
Chemistry
In vivo
Biochemistry
Pharmacology