Chin Siang Kue
Management and Science University
Molecular biologyNanoparticleOrganic chemistryChemistryPhotodynamic therapy
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Publications 9
Abstract Active targeting compound, a non-iodinated derivative of IK-IK-I2-azaBODIPY (1a) was previously reported to preferentially bind melanoma over healthy cells. In this study, we evaluate the photodynamic therapy (PDT) efficiency on melanoma cells of 1a, together with its reversed sequence compound KI-KI-I2-azaBODIPY (1b) and a non-targeted control I2-azaBODIPY-NH2 (2). All three test compounds possess absorption wavelengths in the near-infrared (NIR) region (λmax between 678 and 687 nm) wh...
#2Chin Siang KueH-Index: 4
Last. Beng Fye LauH-Index: 9
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#1Nur ‘Afina Rusdi (Management and Science University)
#2Chin Siang Kue (Management and Science University)H-Index: 4
Last. Lik Voon Kiew (UM: University of Malaya)H-Index: 11
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Despite the extensive work on anticancer drug discovery, the number of potent lead compounds that enter the preclinical and clinical trials thus far is still low due to the poor selectivity and und...
#1Chin Siang Kue (Management and Science University)H-Index: 4
#2Shie Yin Ng (UM: University of Malaya)H-Index: 2
Last. Hong Boon Lee (UM: University of Malaya)H-Index: 7
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BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region. Despite their extraordinary photophysical characteristics, they are not featured in clinical photodynamic therapy. This review discusses the recent advances in the design and/or modifications of BODIPYs since 2013, to improve their potential in photodynamic cancer therapy and related areas.
16 CitationsSource
#1Siew Hui Voon (UM: University of Malaya)H-Index: 6
#2Chin Siang Kue (UM: University of Malaya)H-Index: 4
Last. Shin-ichi Yusa (University of Hyogo)H-Index: 29
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Abstract Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P 71 D 3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P 71 D 3 -based micelle of an average diameter of 100 nm was found to be biocompatible, non-toxic and physically stable in colloidal system up to 15 days. It enhanced the in vitro potency of doxorubicin (DOX) in 4T1 breast tumor cells by increasing its uptake, by 3-fold, compared to free DOX. In 4T1 tumor-bearing m...
3 CitationsSource
#1Yu-Hsuan Hsu (NTUST: National Taiwan University of Science and Technology)H-Index: 2
#2Hui-Ling Hsieh (NTUST: National Taiwan University of Science and Technology)H-Index: 1
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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We functionalized graphene oxide (GO) with cyclodextrin (CD) to increase the drug loading and cellular uptake of GO, and bound the GO-CD to carbon-coated iron nanoparticles (Fe@C) with superparamagnetic properties for potential magnetic-directed drug delivery and as a diagnostic agent. The GO-CD/Fe@C was loaded with an anticancer drug, doxorubicin (DOX), to form a multifunctional GO-CD/Fe@C/DOX nanohybrid. A cumulative increase in DOX loading was observed probably due to DOX adsorption to the gr...
3 CitationsSource
#1Chin Siang KueH-Index: 4
#2Anyanee KamkaewH-Index: 13
Last. Hong Boon LeeH-Index: 10
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Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy
6 CitationsSource
#1Siew Hui VoonH-Index: 6
#2Shu Xian TiewH-Index: 2
Last. Lip Yong ChungH-Index: 19
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13 CitationsSource
#1Chin Siang KueH-Index: 4
#2Anyanee KamkaewH-Index: 13
Last. Kevin BurgessH-Index: 60
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This contribution features a small molecule that binds TrkC (tropomyosin receptor kinase C) receptor that tends to be overexpressed in metastatic breast cancer cells but not in other breast cancer cells. A sensitizer for 1O2 production conjugated to this structure gives 1-PDT for photodynamic therapy. Isomeric 2-PDT does not bind TrkC and was used as a control throughout; similarly, TrkC– cancer cells were used to calibrate enhanced killing of TrkC+ cells. Ex vivo, 1- and 2-PDT where only cytoto...
11 CitationsSource