Impact of the State of Water on the Dispersion Stability of a Skin Cream Formulation Elucidated by Magnetic Resonance Techniques

This study investigated the relationship between the state of water and the dispersion stability of a skin cream formulation. Hydrophilic ointments treated with a high-pressure wet-type jet mill were used as model formulations. Spin-lattice relaxation times (T(1)) were measured by magnetic resonance techniques to estimate the state of water in samples. A shorter T(1) relaxation time was obtained from samples with higher surfactant content,...