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Masato Nishikawa
Hoshi University
Self-healing hydrogelsChemistryJet millPolyacrylic acidSkin Cream
5Publications
4H-index
100Citations
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Publications 5
Newest
#1Masato Nishikawa (Hoshi University)H-Index: 4
#2Yoshinori Onuki (Hoshi University)H-Index: 15
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 4 authors...
This study investigated the relationship between the state of water and the dispersion stability of a skin cream formulation. Hydrophilic ointments treated with a high-pressure wet-type jet mill were used as model formulations. Spin–lattice relaxation times (T1) were measured by magnetic resonance techniques to estimate the state of water in samples. A shorter T1 relaxation time was obtained from samples with higher surfactant content, whereas the processing pressure of the jet mill and 1-week s...
6 CitationsSource
#1Kok Hoong Leong (UM: University of Malaya)H-Index: 10
#2Lip Yong Chung (UM: University of Malaya)H-Index: 19
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 8 authors...
Abstract The work presented herein discusses the carboxymethylation of kappa -carrageenan, a natural linear polysaccharide, to afford a pH-dependent swelling property allowing for intestinal-targeted delivery of bioactive macromolecules. The carboxymethylation conditions with respect to the volume and concentration of sodium hydroxide ( V NaOH , C NaOH ), weight of monochloroacetic acid ( W MCA ), and reaction temperature ( T ) were optimized using a response surface method incorporating a multi...
49 CitationsSource
#1Masato Nishikawa (Hoshi University)H-Index: 4
#2Yoshinori Onuki (Hoshi University)H-Index: 15
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 4 authors...
Background: A high-pressure wet-type jet mill is a powerful equipment used for the dispersion and emulsification of substances. In this study, we investigated its usefulness in the preparation of skin cream formulations. Method: We prepared a hydrophilic ointment base as a typical skin cream base, and then treated it with the wet-type jet mill under different conditions. Controllable factors of the wet-type jet mill included processing pressure, treatment cycle, and temperature of the treatment....
2 CitationsSource
#1Masato Nishikawa (Hoshi University)H-Index: 4
#2Yoshinori Onuki (Hoshi University)H-Index: 15
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 4 authors...
Photocrosslinked polyacrylic acid hydrogel, made from polyacrylic acid (PAA) modified with 2-hydroxyethyl methacrylate (HEMA), is a promising candidate adhesive for dermatological patches. In this study, we investigated the further availability of hydrogel as an adhesive for dermatological patches using a hydrogel containing indomethacin (IDM) as a model anti-inflammatory patch. From an orthogonal experimental study, we clarified the relationships between formulation factors and characteristics ...
13 CitationsSource
#1Yoshinori Onuki (Hoshi University)H-Index: 15
#2Masato Nishikawa (Hoshi University)H-Index: 4
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 4 authors...
Photocrosslinked polyacrylic acid hydrogel is a promising candidate adhesive for dermatological patches. In this study, we investigated the effects of the composition and molecular weight of the polymer on the characteristics of the hydrogel. Several photocrosslinkable polymers with different photocrosslinkable moieties or molecular weights were prepared, and various physical properties were measured. Differences in photocrosslinkable modifications markedly affected the swelling behavior of the ...
30 CitationsSource
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