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Consequences of obstructive sleep apnea on metabolic profile: A Population-Based Survey†

Published on Jun 14, 2012in Obesity 3.97
· DOI :10.1002/oby.20288
Sonia Maria Togeiro15
Estimated H-index: 15
(UNIFESP: Federal University of São Paulo),
Glaucia Carneiro11
Estimated H-index: 11
(UNIFESP: Federal University of São Paulo)
+ 5 AuthorsSérgio Tufik13
Estimated H-index: 13
(UNIFESP: Federal University of São Paulo)
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Abstract
Objective: Epidemiologic studies that control for potential confounders are needed to assess the independent associations of obstructive sleep apnea (OSA) with metabolic abnormalities. The aim of our study was to evaluate the associations of OSA with metabolic abnormalities among the adult population of Sao Paulo, Brazil. Design and Methods: Questionnaires were applied face-to-face, full night polysomnography (PSG) was performed, and blood samples were collected in a population-based survey in Sao Paulo, Brazil, adopting a probabilistic three-stage cluster sample method. The metabolic profile included fasting glucose, insulin, and lipid levels. The hepatic insulin resistance index was assessed by the homeostasis model assessment-estimated insulin resistance (HOMAIR). Results: A total of 1,042 volunteers underwent PSG. Mild OSA and moderate to severe OSA comprised 21.2% and 16.7% of the population, respectively. Subjects with severe to moderate OSA were older, more obese, had higher fasting glucose, HOMAIR, and triglycerides (TG) levels than did the mild and non-OSA group (P < 0.001). Multivariate regression analyses showed that an apnea-hypopnea index (AHI) ≥15 and a time of oxy-hemoglobin saturation <90% were independently associated with impaired fasting glucose, elevated TG, and HOMAIR. Conclusions: The results of this large cross-sectional epidemiological study showed that the associations of OSA and metabolic abnormalities were independent of other risk factors.
  • References (36)
  • Citations (49)
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References36
Newest
Published on Mar 1, 2010in Diabetologia 7.11
Isao Muraki10
Estimated H-index: 10
(Osaka University),
Takeshi Tanigawa30
Estimated H-index: 30
(Ehime University)
+ 9 AuthorsTakashi Shimamoto39
Estimated H-index: 39
Aims/hypothesis Although the associations between obstructive sleep apnoea and type 2 diabetes mellitus have been reported in cross-sectional design studies, findings on the prospective association between the two conditions are limited. We examined prospectively the association between nocturnal intermittent hypoxia as a surrogate marker of obstructive sleep apnoea and risk of type 2 diabetes.
87 Citations Source Cite
Published on Jan 1, 2010in European Respiratory Journal 11.81
J. C. M. Lam1
Estimated H-index: 1
,
B Lam27
Estimated H-index: 27
+ 5 AuthorsMsm Ip12
Estimated H-index: 12
The effects of treatment of obstructive sleep apnoea (OSA) on glucose metabolism have been investigated previously with conflicting results. This study evaluated the impact of nasal continuous positive airway pressure (nCPAP) treatment of OSA on insulin sensitivity. Males with moderate/severe OSA and no significant comorbidity were randomised to a therapeutic or sham nCPAP treatment group for 1 week and then reassessed. Those who received therapeutic nCPAP were further evaluated at 12 weeks. Ins...
117 Citations Source Cite
Published on Dec 1, 2009in Sleep Medicine 3.36
Sergio Tufik29
Estimated H-index: 29
(UNIFESP: Federal University of São Paulo),
Rogerio Santos-Silva17
Estimated H-index: 17
(UNIFESP: Federal University of São Paulo)
+ 1 AuthorsLia Rita Azeredo Bittencourt33
Estimated H-index: 33
(UNIFESP: Federal University of São Paulo)
Abstract Objective To estimate the prevalence of Obstructive Sleep Apnea Syndrome (OSAS), using current clinical and epidemiological techniques, among the adult population of Sao Paulo, Brazil. Methods This population-based survey used a probabilistic three-stage cluster sample of Sao Paulo inhabitants to represent the population according to gender, age (20–80years), and socio-economic status. Face-to-face interviews and in-lab full-night polysomnographies using a nasal cannula were performed. ...
436 Citations Source Cite
Published on Jun 1, 2009in Sleep Medicine 3.36
Rogerio Santos-Silva17
Estimated H-index: 17
(UNIFESP: Federal University of São Paulo),
Sergio Tufik56
Estimated H-index: 56
(UNIFESP: Federal University of São Paulo)
+ 2 AuthorsLia Rita Azeredo Bittencourt33
Estimated H-index: 33
(UNIFESP: Federal University of São Paulo)
Abstract Objectives To present the rational design, sampling, and procedures utilized in an Epidemiologic Sleep Study carried out in 2007 to establish the epidemiologic profile of sleep disorders in the adult population of a large metropolitan city, Sao Paulo, Brazil. Methods A population-based survey adopting a probabilistic three-stage cluster sample of Sao Paulo was used to represent the population according to gender, age (20–80 years), and socioeconomic class. Questionnaires, actigraphy, po...
73 Citations Source Cite
Published on May 1, 2009in Journal of Applied Physiology 3.14
Mariam Louis1
Estimated H-index: 1
(Johns Hopkins University),
Naresh M. Punjabi49
Estimated H-index: 49
Accumulating evidence suggests that obstructive sleep apnea is associated with alterations in glucose metabolism. Although the pathophysiology of metabolic dysfunction in obstructive sleep apnea is not well understood, studies of murine models indicate that intermittent hypoxemia has an important contribution. However, corroborating data on the metabolic effects of intermittent hypoxia on glucose metabolism in humans are not available. Thus the primary aim of this study was to characterize the a...
216 Citations Source Cite
Glaucia Carneiro11
Estimated H-index: 11
,
Sonia Maria Togeiro15
Estimated H-index: 15
+ 4 AuthorsMaria Teresa Zanella19
Estimated H-index: 19
Obstructive sleep apnea syndrome (OSAS) increases the risk of cardiovascular events. Sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis activation may be the mechanism of this relationship. The aim of this study was to evaluate HPA axis and ambulatory blood pressure monitoring in obese men with and without OSAS and to determine whether nasal continuous positive airway pressure therapy (nCPAP) influenced responses. Twenty-four-hour ambulatory blood pressure monitoring and ov...
34 Citations Source Cite
Published on Oct 1, 2007in Journal of the American College of Cardiology 18.64
Andrew Cassar3
Estimated H-index: 3
(UR: University of Rochester),
Timothy I. Morgenthaler2
Estimated H-index: 2
(UR: University of Rochester)
+ 2 AuthorsAmir Lerman17
Estimated H-index: 17
(UR: University of Rochester)
Objectives Our purpose was to compare outcomes of patients treated for obstructive sleep apnea (OSA) versus patients with untreated OSA, all of whom had undergone percutaneous coronary intervention (PCI). Background Obstructive sleep apnea has been associated with increases in fatal and nonfatal cardiovascular events. It is not known whether treatment of OSA in patients who have had PCI results in a better outcome. Methods In a retrospective cohort study, a group of patients with OSA diagnosed w...
138 Citations Source Cite
Published on Sep 1, 2007in Chest 9.66
Paschalis Steiropoulos21
Estimated H-index: 21
,
Venetia Tsara13
Estimated H-index: 13
+ 5 AuthorsDemosthenes Bouros50
Estimated H-index: 50
(DUTH: Democritus University of Thrace)
Background Serum levels of circulating markers associated with cardiovascular morbidity are elevated in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). These factors are studied in patients mainly before the application of therapy with continuous positive airway pressure (CPAP), and the effects of CPAP treatment on them have not been thoroughly studied. Therefore, the aim of the study was to examine the effect of compliance to CPAP therapy on these factors. Methods Patients with...
117 Citations Source Cite
Vladimir Savransky15
Estimated H-index: 15
(Johns Hopkins University),
Ashika Nanayakkara8
Estimated H-index: 8
(Johns Hopkins University)
+ 4 AuthorsVsevolod Y. Polotsky39
Estimated H-index: 39
(Johns Hopkins University)
Rationale: Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A causal link between obstructive sleep apnea and atherosclerosis has not been established. Objectives: The objective of the present study was to examine whether CIH may induce atherosclerosis in C57BL/6J mice. Methods: Forty male C57BL/6J mice, 8 weeks of age, were fed either a high-cholesterol diet or a regular chow d...
279 Citations Source Cite
Published on Jun 1, 2007in Sleep Medicine Clinics
Jonathan C. Jun23
Estimated H-index: 23
(JHUSOM: Johns Hopkins University School of Medicine),
Vsevolod Y. Polotsky39
Estimated H-index: 39
(JHUSOM: Johns Hopkins University School of Medicine)
OSA, the most common form of sleep-disordered breathing, is characterized by recurrent collapse of the upper airway during sleep leading to periods of intermittent hypoxia and sleep fragmentation. There is growing evidence that OSA is associated with metabolic abnormalities and may be implicated in causality of metabolic disorders. OSA is linked to increased risk of hypertension, insulin resistance, glucose intolerance and type 2 diabetes, dyslipidemia, atherosclerosis, and non-alcoholic fatty l...
31 Citations Source Cite
Cited By49
Newest
Published on May 1, 2019in Clinics in Liver Disease 5.23
Malav P. Parikh3
Estimated H-index: 3
(Cleveland Clinic),
Niyati M. Gupta2
Estimated H-index: 2
(Cleveland Clinic),
Arthur J. McCullough59
Estimated H-index: 59
(Cleveland Clinic Lerner College of Medicine)
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Published on Apr 18, 2019in Experimental Diabetes Research
K. Neumann , Michael Arzt25
Estimated H-index: 25
+ 2 AuthorsStefan Stadler1
Estimated H-index: 1
Background. Metabolic syndrome (MS) and sleep-disordered breathing (SDB) are highly prevalent in patients with diabetes mellitus type 2 (DM2). The present study examined whether there is an independent association between SDB and MS in a sample of outpatients with DM2. Methods. MS was determined in 679 patients of the DIACORE-SDB substudy, a study of outpatients with DM2. According to the National Cholesterol Education Program (NCEP) criteria, MS is defined by at least three of the following fiv...
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Published on Mar 1, 2019in Sleep
David Barros1
Estimated H-index: 1
,
Francisco García Río34
Estimated H-index: 34
(UAM: Autonomous University of Madrid)
2 Citations Source Cite
Published on Jan 1, 2019in Sleep Medicine 3.36
Romina Abud1
Estimated H-index: 1
(UdeC: University of Concepción),
Maitte Salgueiro1
Estimated H-index: 1
(University of Valle)
+ 3 AuthorsGonzalo Labarc1
Estimated H-index: 1
Abstract Background Obstructive sleep apnea/Hypoapnea syndrome (OSAHS) is a very common, yet undiagnosed, breathing disorder that has many more implications besides disrupted sleep. Its role as an independent risk factor for metabolic abnormalities such as insulin resistance (IR) and impaired glucose tolerance is becoming increasingly recognized. The main treatment for OSAHS is continuous positive airway pressure (CPAP), however the impact of CPAP on IR and glucose metabolism is still debated. O...
1 Citations Source Cite
Published on Dec 23, 2018in Experimental Diabetes Research
Ye Zhang1
Estimated H-index: 1
(JLU: Jilin University),
Yanpeng Xing1
Estimated H-index: 1
(JLU: Jilin University)
+ 4 AuthorsGuixia Wang6
Estimated H-index: 6
(JLU: Jilin University)
Aims. Obstructive sleep apnea (OSA) is a very common disorder which is associated with metabolic comorbidities. The aims of this study were to analyze clinical data of patients with OSA and evaluate influence of sleep-disordered breathing on glycometabolism and its underlying mechanisms. Methods. We designed a cross-sectional study involving 53 OSA patients in The First Hospital of Jilin University from March 2015 to March 2016. They underwent a full-night polysomnography, measurement of fasting...
1 Citations Source Cite
Published on Dec 1, 2018in Respirology 4.76
Canan Gündüz2
Estimated H-index: 2
(Ege University),
Ozen K. Basoglu15
Estimated H-index: 15
(Ege University)
+ 10 AuthorsPavel Sliwinski1
Estimated H-index: 1
3 Citations Source Cite
Published on Dec 1, 2018
Abdelnaby Khalyfa28
Estimated H-index: 28
(U of C: University of Chicago),
David Gozal89
Estimated H-index: 89
(MU: University of Missouri)
Purpose of Review The purpose of the study is to summarize the potential interactions between obstructive sleep apnea (OSA), atrial fibrillation (AF), and connexins.
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Published on Dec 1, 2018
Gabriel Natan Pires9
Estimated H-index: 9
(UNIFESP: Federal University of São Paulo),
Lia Rita Azeredo Bittencourt33
Estimated H-index: 33
(UNIFESP: Federal University of São Paulo)
+ 1 AuthorsMonica L. Andersen38
Estimated H-index: 38
(UNIFESP: Federal University of São Paulo)
The applicability of sleep medicine into public health policies depends on epidemiological and population-based surveys. The present study aimed to analyze a population-based sample to provide qualitative epidemiological profiles related to obstructive sleep apnea syndrome, by means of a correspondence analysis. The Sao Paulo Epidemiological Sleep Study (EPISONO) dataset was used and variables related to the obstructive sleep apnea syndrome diagnosis, gender, age, self-reported ethnicity, and bo...
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Published on Sep 1, 2018in Sleep and Breathing 2.33
Cathy A. Goldstein3
Estimated H-index: 3
(UM: University of Michigan),
Hala Karnib1
Estimated H-index: 1
(University of Louisville)
+ 2 AuthorsAfifa Shamim-Uzzaman1
Estimated H-index: 1
(UM: University of Michigan)
Purpose Home sleep apnea tests (HSATs) are an alternative to attended polysomnograms (PSGs) when the pre-test probability for moderate to severe OSA is high. However, insurers often mandate use anytime OSA is suspected regardless of the pre-test probability. Our objective was to determine the ability of HSATs to rule in OSA when the pre-test probability of an apnea hypopnea index (AHI) in the moderate to severe range is low.
2 Citations Source Cite
Published on Aug 1, 2018in Sleep Medicine 3.36
Felipe Augusto Folha Santos (UNIFESP: Federal University of São Paulo), Luciane Bizari Coin de Carvalho17
Estimated H-index: 17
(UNIFESP: Federal University of São Paulo)
+ 3 AuthorsJosé Luiz Pedroso17
Estimated H-index: 17
(UNIFESP: Federal University of São Paulo)
Abstract Objective/Background Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is the most common type of autosomal dominant spinocerebellar ataxia (SCA). Sleep disorders have been described as frequent non-motor symptoms in MJD, and with marked impairment on quality of life. However, few studies have evaluated the frequency and characteristics of sleep apnea in MJD. Patients/Methods This study analyzed the prevalence of sleep apnea in 47 patients with MJD by using polysomnog...
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