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Sergio Tufik
Federal University of São Paulo
1,568Publications
56H-index
16.9kCitations
Publications 1568
Newest
#1Beatriz B. M. Bambini (UNIFESP: Federal University of São Paulo)
#2Rosa Maria Affonso Moysés (USP: University of São Paulo)H-Index: 27
Last.Fernando Morgadinho Coelho (UNIFESP: Federal University of São Paulo)H-Index: 10
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#1Laís D. Rodrigues (UNIFESP: Federal University of São Paulo)
#2Leandro Freitas Oliveira (UNIFESP: Federal University of São Paulo)
Last.Fulvio A. Scorza (UNIFESP: Federal University of São Paulo)H-Index: 30
view all 7 authors...
Abstract Dijkstra and collaborators provide interesting and important issue in clinical research addressing REM sleep without atonia as a possible prodromal marker for Lewy body disease, an early finding in Parkinson's disease. Though prodromal studies are relevant, it is also mandatory to consider the causes of mortality of Parkinson's disease once it is stablished, such as Sudden Unexpected Death in Parkinson's Disease.
#1Mario Pedrazzoli (USP: University of São Paulo)H-Index: 15
#2Diego Robles Mazzotti (UPenn: University of Pennsylvania)H-Index: 13
Last.Sergio Tufik (UNIFESP: Federal University of São Paulo)H-Index: 56
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Glutamate is the most excitatory neurotransmitter in the central nervous system and it is involved in the initiation and maintaining of waking and rapid-eye-movement (REM) sleep. Homer proteins act in the trafficking and/or clustering of metabotropic glutamate receptors, and polymorphisms in the HOMER1 gene have been associated with phenotypes related to glutamate signaling dysregulation. In this study, we report the association of a single nucleotide polymorphism (SNP) in the HOMER1 gene (rs382...
#1Priscila K Morelhão (UNIFESP: Federal University of São Paulo)
#2Rafael Z. Pinto (UFMG: Universidade Federal de Minas Gerais)H-Index: 19
Last.Monica L. Andersen (UNIFESP: Federal University of São Paulo)H-Index: 38
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#1Rachel Gimenes Albuquerque (UNIFESP: Federal University of São Paulo)H-Index: 3
#2Sergio Tufik (UNIFESP: Federal University of São Paulo)H-Index: 56
Last.Monica L. Andersen (UNIFESP: Federal University of São Paulo)H-Index: 38
view all 3 authors...
#1Nicole Hosni Dittrich (UNIFESP: Federal University of São Paulo)
#2Gabriel Natan Pires (UNIFESP: Federal University of São Paulo)H-Index: 9
Last.Monica L. Andersen (UNIFESP: Federal University of São Paulo)H-Index: 38
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O uso de animais para fins didaticos e de pesquisa requer cuidados especificos. Atualmente, vigora no Brasil a Lei 11.794/2008, que rege parâmetros legais de manejo e conduta neste caso. Esta lei foi acompanhada da instalacao ou adequacao de comissoes de etica em instituicoes que utilizam animais para ensino e investigacao, bem como da criacao do Conselho Nacional de Controle de Experimentacao Animal. No entanto, apesar dos avancos, especialmente na legislacao, ainda nao foi consolidada nenhuma ...
Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1−/−) is described showing that they are viable, have estrus cycle, fertility, and a number of puppies per litter similar to C57BL/6 wild type mice (WT). In specific brain regions, THOP1-/- exhibit altered mRNA expression of proteasome beta5, serotonin 5HT2a receptor and dopamine D2 receptor, but not of...
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