Papers 5580
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#2Qibin WangH-Index: 1
Last. Li ChenH-Index: 1
view all 8 authors...
OBJECTIVE This study aimed to investigate whether the NLRP3 inflammasome in Kupffer cells (KCs) can be activated in response to high glucose (HG) and to evaluate its influence on hepatic insulin sensitivity. METHODS Primary KCs and hepatocytes were isolated from mice, and lipid accumulation, glucose output, and insulin sensitivity of hepatocytes were investigated after culturing either alone or with KCs exposed to HG. The influence of HG-induced NLRP3 inflammasome activation in KCs on insulin se...
#1Soo Lim (Seoul National University Bundang Hospital)H-Index: 42
#2Hyunjung Lim (Kyung Hee University)H-Index: 7
Last. Jean-Pierre Després (Laval University)H-Index: 118
view all 3 authors...
ABSTRACT A novel coronavirus (SARS-CoV-2), that emerged in the city of Wuhan, China in December 2019, has now spread worldwide
#1Rebeca Mendez-Hernandez (UNAM: National Autonomous University of Mexico)H-Index: 1
#2Carolina Escobar (UNAM: National Autonomous University of Mexico)H-Index: 30
Last. Ruud M. Buijs (UNAM: National Autonomous University of Mexico)H-Index: 75
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In mammals, time and metabolism are tightly coupled variables; this relationship can be illustrated by numerous examples, such as the circadian variation in food intake or the circadian response to a glucose bolus. We review evidence that the interaction between suprachiasmatic nucleus and arcuate nucleus plays a key role in the execution of these functions. The nuclei are reciprocally connected via different projections, and this interaction provides an ideal anatomical framework to modify the ...
#1Emily Qualls-Creekmore (Pennington Biomedical Research Center)H-Index: 10
#2Kara L. Marlatt (Pennington Biomedical Research Center)H-Index: 9
Last. Helen E. Raybould (UC Davis: University of California, Davis)H-Index: 54
view all 17 authors...
This review details the proceedings of a Pennington Biomedical scientific symposium titled, "What Should I Eat and Why? The Environmental, Genetic, and Behavioral Determinants of Food Choice." The symposium was designed to review the literature about energy homeostasis, particularly related to food choice and feeding behaviors, from psychology to physiology. This review discusses the intrinsic determinants of food choice, including biological mechanisms (genetics), peripheral and central signals...
#1W. Garvey (UAB: University of Alabama at Birmingham)H-Index: 52
#2Jeffrey I. Mechanick (Mount Sinai Hospital)H-Index: 5
#1Peng Zhang (Capital Medical University)H-Index: 1
Last. Mei Jin (Capital Medical University)
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OBJECTIVE This study aimed to investigate regional neural activity and regulation of patterns in the reorganized neural network of obesity and explore the correlation between brain activities and eating behavior. METHODS A total of 23 individuals with obesity and 23 controls with normal weight were enrolled. Functional magnetic resonance imaging (fMRI) data were acquired using 3.0-T MRI. Amplitude of low-frequency fluctuation and functional connectivity (FC) analyses were conducted using Data Pr...
#1Jun Lu (University of Medicine and Health Sciences)
#2Yuying Gu (Pennington Biomedical Research Center)
Last. Xilin Yang (Tianjin Medical University)H-Index: 36
view all 11 authors...
OBJECTIVE This study aimed to investigate the association of daily branched-chain amino acid (BCAA) intake with the risks of obesity and insulin resistance in children of mothers with gestational diabetes mellitus (GDM). METHODS Daily BCAA intake was calculated by using a validated food frequency questionnaire in 996 children of mothers with GDM. The odds ratios (ORs) (95% CI) of childhood obesity and insulin resistance were obtained using logistic regression models. RESULTS The multivariable-ad...
#1Zoe Mestre (UCSD: University of California, San Diego)H-Index: 3
#2Amanda Bischoff-Grethe (UCSD: University of California, San Diego)H-Index: 22
Last. Kerri N. Boutelle (UCSD: University of California, San Diego)H-Index: 36
view all 8 authors...
OBJECTIVE The hippocampus is a key structure in feeding behaviors and weight regulation. Obesity may lead to disruptions in hippocampal structure. In animals, obesity-related factors (e.g., high-fat/sugar foods) are associated with hippocampal insult (e.g., alterations in the blood brain barrier). In humans, individuals with obesity, relative to healthy weight, have smaller hippocampal volumes. Few studies have examined the association between body weight and the hippocampus during adolescence, ...
#1Karine Clément (University of Paris)H-Index: 15
#2Muriel Coupaye (University of Paris)H-Index: 17
Last. Olivier ZieglerH-Index: 27
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Despite repeated efforts by the international scientific community, academic societies and the combined actions of patient associations, public authorities have difficulties in admitting that obesity is not just a risk factor but a disease. Could our current experience with the COVID-19 pandemic be a lever to advance the cause of people with obesity? In this crisis, it seems pertinent to report on the French experience with the actions of stakeholders that were able to challenge the status quo i...
#1Nawfal W. Istfan (BMC: Boston Medical Center)H-Index: 14
#2Wendy A. Anderson (BMC: Boston Medical Center)H-Index: 9
Last. Caroline M. Apovian (BMC: Boston Medical Center)H-Index: 48
view all 6 authors...
OBJECTIVE: Weight regain (WR) after Roux-en-Y gastric bypass surgery (RYGB) starts to occur 2 years after surgery, ultimately affecting at least 25% of patients. A limited number of studies have evaluated the impact of antiobesity medications (AOMs) on this phenomenon. METHODS: This study reviewed the electronic medical records of 1,196 patients who underwent RYGB between 2004 and 2015. WR was evaluated by comparing each patient's weight during subsequent postoperative office visits to nadir wei...
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Top fields of study
Diabetes mellitus