Original paper
Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition
Abstract
Vaccinations with Abeta1-42 have been shown to reduce amyloid burden in transgenic models of Alzheimer's disease (AD). We have further tested the efficacy of Abeta1-42 immunization in the Tg2576 mouse model of AD by immunizing one group of mice with minimal Abeta deposition, one group of mice with modest Abeta deposition, and one group with significant Abeta deposition. The effects of immunization on Abeta deposition were examined using...
Paper Details
Title
Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition
Published Date
Sep 1, 2001
Journal
Volume
22
Issue
5
Pages
721 - 727
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Notes
History