Nicotinamide-induced modification of hepatic MFO systems in tumour-bearing rats, treated with anti-cancer drugs
Abstract
Chemotherapeutic drugs like cyclophospamide (100 mg/kg b.wt.) and 5-fluorouracil (120 mg/kg b.wt.) caused significant inhibition in cytochrome P450 (cytP450)-dependent hepatic microsomal drug metabolising enzymes in rats. A similar decrease in these enzyme activities was also seen in the host liver of tumour-bearing animals. However, a non-toxic, endogenous (vitamin B3) metabolite, nicotinamide (100 mg/kg b.wt.) could effectively restore the...
Paper Details
Title
Nicotinamide-induced modification of hepatic MFO systems in tumour-bearing rats, treated with anti-cancer drugs
Published Date
Dec 1, 1996
Journal
Volume
109
Issue
1-2
Pages
85 - 90
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