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#1Silvia MatteoniH-Index: 6
#2Claudia AbbruzzeseH-Index: 11
Last.Marco G. PaggiH-Index: 32
view all 7 authors...
Abstract Gliomas are tumors that originate from the glial tissue, thus involving the central nervous system with varying degrees of malignancy. The most aggressive and frequent form is glioblastoma multiforme, a disease characterized by resistance to therapies, frequent recurrences, and extremely poor median survival time. Data on overall glioma case studies demonstrate clear sex disparities regarding incidence, prognosis, drug toxicity, clinical outcome, and, recently, prediction of therapeutic...
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#1Lianghai Wang (Shihezi University)H-Index: 2
#2Zhiyu Zhang (Shihezi University)H-Index: 2
Last.Feng Li (Shihezi University)H-Index: 17
view all 13 authors...
Abstract Deregulation of SOX9 in esophageal cancer has been reported. However, the regulatory mechanisms underlying SOX9 during esophageal squamous cell carcinoma (ESCC) progression remain poorly understood. Here, we independently confirmed the increased SOX9 expression in two ESCC cohorts and its correlation with poor prognosis. We demonstrated that SOX9 was required for maintaining self-renewal, motility, and chemoresistance in vitro and that ectopic expression of SOX9 promoted tumorigenicity ...
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#1Du-Bois Asante (ECU: Edith Cowan University)
#2Leslie Calapre (ECU: Edith Cowan University)H-Index: 6
Last.Elin S. Gray (ECU: Edith Cowan University)H-Index: 31
view all 5 authors...
Abstract Liquid biopsies hold the potential to inform cancer patient prognosis and to guide treatment decisions at the time when direct tumor biopsy may be impractical due to its invasive nature, inaccessibility and associated complications. Specifically, circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) have shown promising results as companion diagnostic biomarkers for screening, prognostication and/or patient surveillance in many cancer types. In ovarian cancer (OC), CTC and ct...
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#1Shan-Shan Guo (SYSU: Sun Yat-sen University)H-Index: 3
#2Rui Liu (SYSU: Sun Yat-sen University)
Last.Hai-Qiang Mai (SYSU: Sun Yat-sen University)H-Index: 4
view all 21 authors...
Abstract Patients with recurrent nasopharyngeal carcinoma (NPC) have more co-existing distant metastasis than those of no-recurrence and are more likely to suffer distant metastasis after re-irradiation than patients with newly diagnosed NPC. However, the relationship between radioresistance and distant metastasis and the mechanisms involved in radioresistance-associated metastasis are still unclear. In this study, we proved that C–C motif chemokine ligand 2 (CCL2) expression was significantly e...
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#1Zhiyuan Shen (Fudan University)
#2Le Zhou (JLU: Jilin University)
Last.Jun Xu (Fudan University)
view all 4 authors...
Abstract Dysregulation of circular RNA Foxo3 (circFoxo3) has been reported to be involved in breast cancer and non-small lung cancer progression. However, little is known about the role of circFoxo3 in prostate cancer, which the present study seeks to investigate. CircFoxo3 expression was analyzed in 22 low-grade prostate cancer samples, 24 high-graded prostate cancer samples, and 18 normal prostate tissues, finding that its quantity was significantly decreased in high-graded compared to low-gra...
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#1Dawei YangH-Index: 8
#2Yang Liu (ISMMS: Icahn School of Medicine at Mount Sinai)
Last.Charles A. Powell (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 34
view all 5 authors...
Abstract Lung cancer is a heterogeneous disease, which is impacted by environmental exposures and by constitutional genetic or epigenetic susceptibilities to disease development and progression. The United States and China have distinct but diverse populations and geographic environmental exposures that contribute to unique patterns of lung cancer incidence and mortality. In this paper, the authors compare trends of incidence and mortality of lung cancer in the US and China, and the impact on lu...
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#1Mark Bates (Trinity College, Dublin)H-Index: 19
#2Fiona Furlong ('QUB': Queen's University Belfast)H-Index: 13
Last.John J. O'LearyH-Index: 45
view all 7 authors...
Abstract MAD2 is an intriguing protein, which has been associated with poor survival in cancer. Depending on the organ-specific cancer, either high expression or low expression levels have been correlated with low survival rates in patients. MAD2 is also a marker of contradiction. The normal function of MAD2 is to accumulate at kinetochores and generate a wait signal preventing the cell from progressing to anaphase of the cell cycle until the spindle microtubules have correctly aligned with the ...
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#1Qiong Chen ('SMMU': Second Military Medical University)
#2Tao Liu ('SMMU': Second Military Medical University)
Last.Linhui Wang ('SMMU': Second Military Medical University)H-Index: 19
view all 10 authors...
Abstract Circular RNAs (circRNAs) are reported to act as important regulators in cancers. CircRNA RAPGEF5 (cRAPGEF5) is derived from exons 2-6 of the RAPGEF5 gene and may promote papillary thyroid cancer progression. However, the role of cRAPGEF5 in renal cell carcinoma (RCC) remains unclear. In this study, we found cRAPGEF5 to be significantly downregulated in RCC tissues. Among 245 RCC cases, cRAPGEF5 downregulation correlated positively with aggressive clinical characteristics and independent...
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#1Yuchen Jin (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Min Liu (Fudan University)H-Index: 11
Last.Libo Chen (SJTU: Shanghai Jiao Tong University)H-Index: 3
view all 6 authors...
Abstract Due to a global increase in the incidence of thyroid cancer, numerous novel mouse models were established to reveal thyroid cancer pathogenesis and test promising therapeutic strategies, necessitating a comprehensive review of translational medicine that covers (i) the role of mouse models in the research of thyroid cancer pathogenesis, and (ii) preclinical testing of potential anti-thyroid cancer therapeutics. The present review article aims to: (i) describe the current approaches for ...
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#1Jie Lv (Ha Tai: Xiamen University)H-Index: 2
#2Sheng Zhang (HUST: Huazhong University of Science and Technology)H-Index: 8
Last.Zhen-YuYin (Ha Tai: Xiamen University)H-Index: 17
view all 12 authors...
Abstract Hepatocellular carcinoma (HCC) has emerged as one of the most common malignancies worldwide. It is associated with a high mortality rate, as evident from its increasing incidence and extremely poor prognosis. The deubiquitinating enzyme 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) has been reported to act as an oncogene in several human cancers. The present study aimed to reveal the functional significance of PSMD14 in HCC progression and the underlying mechanisms. We found ...
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