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Papers 14466
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#1Oliver Bozinov (UZH: University of Zurich)H-Index: 19
#2Yang Yang (UZH: University of Zurich)H-Index: 1
Last.Peter Nakaji (UA: University of Arizona)
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Abstract Laser interstitial thermal therapy (LITT) has been used for brain metastasis, epilepsy, and necrosis, as well as gliomas as a minimally invasive treatment for many years. With the improvement of the thermal monitoring and ablation precision, especially the application of magnetic resonance (MR) thermography in the procedure and the available two commercial laser systems nowadays, LITT is gradually accepted by more neurosurgical centers. Recently, some new concepts, for example the adjuv...
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Last.Om Tirado (ISCIII: Carlos III Health Institute)H-Index: 2
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ABSTRACT Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. Patients with the most aggressive histological variant have an unfavorable prognosis due to a high metastasis incidence. Lysyl oxidase-like 2 (LOXL2) is a lysyl oxidase, member of a family of extracellular matrix (ECM) crosslinking enzymes that recently have emerged as important regulators of tumor progression and metastasis. We report that LOXL2 is overexpressed in RMS, suggesting a potential...
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#1Yan Zhang (WHU: Wuhan University)
#2Xin Li (WHU: Wuhan University)
Last.Hua Liang (WHU: Wuhan University)
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ABSTRACT Long noncoding RNAs play significant roles in diverse cancers. In this study, we found that LINC00240 expression was markedly increased in cervical cancer. Functional in vitro assays in cervical cancer cells showed that LINC00240 enhanced the growth, migration, and invasion of cervical cancer cells. The target of LINC00240 was confirmed as microRNA(miR)-124-3p. Inhibition of miR-124-3p significantly enhanced cervical cancer progression via targeting of STAT3, which is greatly activated ...
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#1Etna Abad (UPF: Pompeu Fabra University)H-Index: 2
#2Dmitry Graifer (NSU: Novosibirsk State University)H-Index: 4
Last.Alex LyakhovichH-Index: 16
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Abstract The cancer stem cell (CSC) model defines tumors as hierarchically organized entities, containing a small population of tumorigenic CSC, or tumour-initiating cells, placed at the apex of this hierarchy. These cells may share common qualities with chemo- and radio-resistant cancer cells and contribute to self-renewal activities resulting in tumour formation, maintenance, growth and metastasis. Yet, it remains obscure what self-defense mechanisms are utilized by these cells against the che...
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#1Karrie M.Y. Kiang (HKU: University of Hong Kong)H-Index: 7
#2Pingde Zhang (HKU: University of Hong Kong)H-Index: 2
Last.Gilberto Ka Kit Leung (HKU: University of Hong Kong)H-Index: 23
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Abstract Adducin 3 (ADD3) is a crucial assembly factor in the actin cytoskeleton and has been found to be aberrantly expressed in various cancers, including glioblastoma multiforme (GBM). It has previously been studied in array-based studies with controversial findings as to its functional role in glioma. In microarray analyses of 452 glioma specimens, we found significant downregulation of ADD3 in GBM, but not in less malignant gliomas, compared to normal brain tissue, which suggests that its d...
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#1Dong Wang (Capital Medical University)H-Index: 1
#2Xiaohui Wang (Capital Medical University)H-Index: 2
Last.Xinfeng Yu (Capital Medical University)H-Index: 9
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Abstract Tumor-associated macrophages (TAMs) are important immunocytes associated with cancer metastasis. However, whether TAMs play a dominant role in mediating CXCL12/CXCR4-induced liver metastasis of colorectal cancer (CRC) remains unexplored. Herein, we found that CD206+ TAMs, which infiltrated at the invasive front, were correlated with CXCR4 expression and liver metastasis of CRC in clinical specimens. Several miRNAs (miR-25-3p, miR-130b-3p, miR-425-5p), upregulated in CRC cells by activat...
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#1Fernando Flores-Guzmán (UNAM: National Autonomous University of Mexico)H-Index: 1
#2Jochen Utikal (DKFZ: German Cancer Research Center)H-Index: 41
Last.Viktor Umansky (DKFZ: German Cancer Research Center)H-Index: 32
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Abstract Melanoma is an aggressive form of skin-cancer. Melanoma cells are characterized by their plasticity, resulting in therapy resistance. Using RET transgenic mouse melanoma model, we characterized dormant tumor cells accumulated in the bone marrow (BM) and investigated their interaction with effector memory CD8+ T cells. We found that cells expressing melanoma-associated antigen tyrosinase related protein (TRP)-2 and stemness marker CD133 represented less than 1.5% of all melanoma cells in...
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#1Jiao-Jiao Yu (Peking Union Medical College)H-Index: 8
#2Dan-dan Zhou (Peking Union Medical College)H-Index: 2
Last.Fang Hua (Peking Union Medical College)H-Index: 20
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Abstract Despite the success of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in the treatment of non-small cell lung cancer (NSCLC) harboring EGFR-activating mutations, intrinsic or acquired resistance remains the major obstacle to long-term disease remission. Defective autophagy has been reported as an EGFR-TKI resistance mechanism. However, how EGFR regulate autophagic flux are still not fully understood. Here we found that EGFR-stimulated phosphorylation of SQSTM1...
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Abstract Although cancer was originally considered a disease driven only by genetic mutations, it has now been proven that it is also an epigenetic disease driven by DNA hypermethylation-associated silencing of tumor suppressor genes and aberrant histone modifications. Very recently, a third component has emerged: the so-called epitranscriptome understood as the chemical modifications of RNA that regulate and alter the activity of RNA molecules. In this regard, the study of genetic and epigeneti...
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#1Huiying Huang (DKFZ: German Cancer Research Center)
#2Michael Zepp (DKFZ: German Cancer Research Center)H-Index: 6
Last.Martin R. Berger (DKFZ: German Cancer Research Center)H-Index: 38
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Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease, and novel therapeutic strategies are urgently needed. Recently, expression of the C-C chemokine receptor 5 (CCR5) and its ligands has been found to play an important role in cancer progression and metastasis. In this study, we blocked the CCR5 receptor by the FDA approved antagonist maraviroc (MVC) in Suit2-007 and MIA-PaCa-2 human PDAC cells. The treatment significantly inhibited their proliferation and induced apoptos...
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