POD-04.05: Detection of TMPRSS2-ERG and TMPRSS2-ETV1 Fusion Genes in Prostate Cancer and Benign Prostate Hyperplasia

Recent studies have reported that a high proportion of prostate cancers express fusion genes. These fusion genes occur when the 5' region of the androgen regulated TMPRSS2 gene merges with one of the ETS family transcription factors, mainly ERG and rarely ETV1 and ETV4. The presence of these fusions has been tested in a subset of high grade PIN lesions and in a small number of benign prostatic hyperplasia...