Original paper
SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses
Abstract
We still know very little about how the human immune system responds to SARS-CoV-2. Here we construct a SARS-CoV-2 proteome microarray containing 18 out of the 28 predicted proteins and apply it to the characterization of the IgG and IgM antibodies responses in the sera from 29 convalescent patients. We find that all these patients had IgG and IgM antibodies that specifically bind SARS-CoV-2 proteins, particularly the N protein and S1 protein....
Figures & Tables
Fig. 1 The workflow of SARS-CoV-2 proteome microarray fabrication and serum prof...
Fig. 2 SARS-CoV-2 proteome microarray layout and quality control. a There are 14...
Fig. 3 The overall SARS-CoV-2-specific IgG profiles of the 29 convalescent sera ...
Fig. 4 The overall SARS-CoV-2-specific IgM profiles of the 29 convalescent sera ...
Fig. 6 IgG response to other SARS-CoV-2 proteins. a Other SARS-CoV-2 proteins th...
Fig. 7 Correlations with clinical characteristics. a–d Correlations of S1 IgG re...
Paper Details
Title
SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses
Published Date
Jul 14, 2020
Journal
Volume
11
Issue
1
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