Intranasal delivery of BDNF rescues memory deficits in AD11 mice and reduces brain microgliosis
Volume: 33, Issue: 5, Pages: 1223 - 1238
Published: Jul 16, 2020
Abstract
A decrease in brain-derived neurotrophic factor (BDNF), a neurotrophin essential for synaptic function, plasticity and neuronal survival, is evident early in the progression of Alzheimer’s disease (AD), being apparent in subjects with mild cognitive impairment or mild AD, and both proBDNF and mature BDNF levels are positively correlated with cognitive measures. BDNF delivery is, therefore, considered of great interest as a potentially useful...
Paper Details
Title
Intranasal delivery of BDNF rescues memory deficits in AD11 mice and reduces brain microgliosis
Published Date
Jul 16, 2020
Volume
33
Issue
5
Pages
1223 - 1238
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