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Aging Clinical and Experimental Research
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Safinamide (SF) is a third-generation monoamine-oxidase-B inhibitor that proved efficacy as add-on to levodopa in fluctuating Parkinson's disease (PD) patients. Despite the high prevalence of complicated PD in older population, the data on the tolerability, safety and efficacy of SF in elderly patients are rather poor. Here we studied retrospectively the consequences of add-on with SF in PD patients older than 65 years. Fifty-three fluctuating PD patients were included (30 subjects aged between ...
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A decrease in brain-derived neurotrophic factor (BDNF), a neurotrophin essential for synaptic function, plasticity and neuronal survival, is evident early in the progression of Alzheimer's disease (AD), being apparent in subjects with mild cognitive impairment or mild AD, and both proBDNF and mature BDNF levels are positively correlated with cognitive measures. BDNF delivery is, therefore, considered of great interest as a potentially useful therapeutic strategy to contrast AD. Invasive BDNF adm...
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#1Francesca Remelli (University of Ferrara)H-Index: 1
#2Maura Bugada (University of Ferrara)
Last. Stefano Volpato (University of Ferrara)H-Index: 55
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#1Annele Urtamo (UH: University of Helsinki)H-Index: 3
#2S.K. Jyväkorpi (UH: University of Helsinki)H-Index: 6
Last. Timo E. Strandberg (University of Oulu)H-Index: 60
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#1Antonello Maruotti (University of Bergen)H-Index: 19
#2Filippo Belloc (UNISI: University of Siena)H-Index: 10
Last. Antonio Nicita (Libera Università Maria SS. Assunta)
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#1Angelo BianchettiH-Index: 43
#2Giuseppe Bellelli (University of Milano-Bicocca)H-Index: 38
Last. Marco TrabucchiH-Index: 61
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The SARS-CoV-2 pandemic has led to a dramatic crisis of Health Care Systems worldwide, and older people have been among the most disadvantaged. Specific recommendations and reports have been released both at International and National level, regarding the diagnosis and management of COVID-19 in the elderly. However, little has been proposed for an appropriate response to older, frail and multimorbid patients in different settings of care (acute care units, long term care facilities, nursing home...
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BACKGROUND Surgical outcomes in geriatric patients may be complicated by factors such as multiple comorbidities, low functional performance, frailty, reduced homeostatic capacity, and cognitive impairment. An integrated multidisciplinary approach to management is, therefore, essential in this population, but at present, the use of such an approach is uncommon. The Perioperative Management of Elderly patients (PriME) project has been established to address this issue. AIMS To develop evidence-bas...
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#1Mario BoH-Index: 23
#2Enrico BrunettiH-Index: 5
Last. Gianluca IsaiaH-Index: 16
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#1S.K. JyväkorpiH-Index: 6
#2Annele Urtamo (UH: University of Helsinki)H-Index: 3
Last. Timo E. Strandberg (University of Oulu)H-Index: 60
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BACKGROUND Habitual coffee drinking has been associated with lower risk of various chronic diseases linked to poor physical performance. OBJECTIVE We explored cross-sectional associations between coffee consumption and physical performance among oldest-old community-dwelling men in the Helsinki Businessmen Study (HBS). METHODS A random sample of HBS survivors (n = 126, mean age 87 years) attended a clinic visit in 2017/2018, including measurements of body composition, physical performance [Short...
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#1Haiying Sun (HUST: Huazhong University of Science and Technology)H-Index: 8
#2Ruoqi Ning (HUST: Huazhong University of Science and Technology)H-Index: 2
Last. Fangxu Tang (HUST: Huazhong University of Science and Technology)H-Index: 5
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BACKGROUND The potential differences between a clinical diagnosis of coronavirus disease 2019 (COVID-19) (i.e., symptoms without positive virus test) and a microbiological diagnosis (i.e., positive virus test results) of COVID-19 are not known. AIMS This study explored the differences between the two types of COVID-19 diagnosis among older patients in terms of clinical characteristics and outcomes. METHODS A total of 244 inpatients aged ≥ 60 years with COVID-19 were included in this study, of wh...
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