Original paper

Membrane protein CAR promotes hematopoietic regeneration upon stress

Volume: 106, Issue: 8, Pages: 2180 - 2190
Published: Jun 25, 2020
Abstract
Adult hematopoietic stem cells (HSCs) are quiescent most of the time, and how HSCs switch from quiescence to proliferation following hematopoietic stress is unclear. Here we demonstrate that upon stress the coxsackievirus and adenovirus receptor CAR (also known as CXADR) is upregulated in HSCs and critical for HSC entry into the cell cycle. WT HSCs were detected more rapid repopulation ability than the CAR cKO counterparts. After 5-FU treatment,...
Paper Details
Title
Membrane protein CAR promotes hematopoietic regeneration upon stress
Published Date
Jun 25, 2020
Volume
106
Issue
8
Pages
2180 - 2190
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