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#1Aidan G. Gilmartin (GSK: GlaxoSmithKline)H-Index: 11
#2Arthur Groy (GSK: GlaxoSmithKline)H-Index: 9
Last. Daniela Ennulat (GSK: GlaxoSmithKline)H-Index: 12
view all 23 authors...
Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy for the management of beta-hemoglobinopathies such as sickle cell disease. DNA methyltransferase (DNMT) inhibitors 5-azacytidine (5-aza) and 5-aza-2'-deoxycytidine (decitabine) have been shown to induce fetal hemoglobin expression in both preclinical models and clinical studies, but are not currently approved for the management of hemoglobinopathies. We report here the discovery of a novel class o...
Neutrophil extracellular traps (NETs) induce a procoagulant response linking inflammation and thrombosis. Low levels of miR-146a, a brake of inflammatory response, are involved in higher risk for cardiovascular events, but the mechanisms explaining how miR-146a exerts its function remain largely undefined. The aim of this study was to explore the impact of miR-146a deficiency in NETosis both, in sterile and non-sterile models in vivo, and to inquire into the underlying mechanism. Two models of i...
#1Andreas Agathangelidis (UniSR: Vita-Salute San Raffaele University)H-Index: 18
#2Chrysi GaligalidouH-Index: 2
Last. Frederic Davi (University of Paris)H-Index: 48
view all 13 authors...
#1Keiichiro Watanabe (University of Tokushima)H-Index: 6
#2Ariunzaya Bat-Erdene (Mongolian National University)
Last. Kimiko Sogabe (University of Tokushima)H-Index: 2
view all 19 authors...
#1Fredrik H. Schjesvold (University of Oslo)H-Index: 11
#2Paul G. Richardson (Harvard University)H-Index: 162
Last. Sophie GuillonneauH-Index: 1
view all 16 authors...
#1Louis DrevonH-Index: 3
#2Nabih MaslahH-Index: 4
Last. Marie-Hélène SchlageterH-Index: 17
view all 15 authors...
#1Guojin Wu (UTSW: University of Texas Southwestern Medical Center)
#2Cheng Cheng Zhang (UTSW: University of Texas Southwestern Medical Center)H-Index: 34
Adult hematopoietic stem cells (HSCs) are quiescent most of the time, and how HSCs switch from quiescence to proliferation following hematopoietic stress is unclear. Here we demonstrate that upon stress the coxsackievirus and adenovirus receptor CAR (also known as CXADR) is upregulated in HSCs and critical for HSC entry into the cell cycle. WT HSCs were detected more rapid repopulation ability than the CAR cKO counterparts. After 5-FU treatment, CAR cKO HSCs had lower levels of Notch1 expression...
#1Laura MagnanoH-Index: 11
#2Alba NavarroH-Index: 28
Last. Eva GinéH-Index: 37
view all 17 authors...
#2Stella M. DaviesH-Index: 52
Last. Joseph Chewing (UAB: University of Alabama at Birmingham)
view all 22 authors...
With limited data comparing hematopoietic cell transplant outcomes between myeloablative total body irradiation (TBI) containing and non-TBI regimens in children with de novo acute myeloid leukemia, the aim of this study was to compare transplant-outcomes between these regimens. Cox regression models were used to compare transplant-outcomes after TBI and non-TBI regimens in 624 children transplanted between 2008 and 2016. Thirty two percent (n=199) received TBI regimens whereas 68% (n=425) recei...
The acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder with laboratory findings similar to those of inherited von Willebrand disease. However, unlike the inherited disease, the AVWS occurs in persons with no personal or family history of bleeding and is often associated with a variety of underlying diseases, most frequently lymphoproliferative, myeloproliferative and cardiovascular disorders. After the presentation of a typical case, in this narrative review we discuss the more ...
Top fields of study
Myeloid leukemia
Bone marrow
Diabetes mellitus