A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data
Volume: 29, Issue: 9, Pages: 1731 - 1738
Published: Sep 1, 2020
Abstract
A polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. Here, we assess the potential impact of PHS-informed screening.United Kingdom population incidence data (Cancer Research United Kingdom) and data from the Cluster Randomized Trial of PSA Testing for Prostate Cancer were combined to estimate...
Paper Details
Title
A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data
Published Date
Sep 1, 2020
Volume
29
Issue
9
Pages
1731 - 1738
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