Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study

Advanced paternal age (APA) is a risk factor for several neurodevelopmental disorders, including autism and schizophrenia. The potential mechanisms conferring this risk are poorly understood. Here, we show that the personality traits schizotypy and neuroticism correlated with paternal age in healthy subjects ( N = 677). Paternal age was further positively associated with gray matter volume (VBM, N = 342) in the right prefrontal and the right...