Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2–Dependent Mechanism in Polycystic Kidney Disease

Significance Statement In autosomal dominant polycystic kidney disease (ADPKD), progressive fibrosis contributes to renal failure, leading to ESKD. The vasopressin type-2 receptor (V2R) helps to regulate renal water homeostasis and stimulates cyst expansion in ADPKD. We discovered a novel pathogenic pathway behind V2R regulation of fibrosis in ADPKD kidneys. Epithelial V2R stimulation activates interstitial myofibroblasts, in a paracrine manner,...