Reductions in albuminuria with SGLT2 inhibitors: a marker for improved renal outcomes in patients without diabetes?

Very high albuminuria (>300 mg per day) is a clear indicator of kidney disease and its reduction is considered the hallmark of long-term slowing of chronic kidney disease progression. A sustained 30% reduction in albuminuria over a year or longer has been associated with slowed nephropathy progression and is considered a marker of renal benefit. 1 Coresh J Heerspink HJL Sang Y et al. Change in albuminuria and subsequent risk of end-stage kidney...