P0221SOLUBLE UROKINASE RECEPTOR (SUPAR) IS A PREDICTOR OF DISEASE STATE AND RENAL PROGNOSIS IN PRIMARY NEPHROTIC SYNDROME

Background and Aims A hypothesis has been proposed that serum (s-) soluble urokinase receptor (suPAR) activates glomerular podocyte β3 integrin to cause podocyte injury and onset of proteinuria in primary nephrotic syndrome (pNS). However, s-suPAR has been questioned as a disease marker for pNS because it did not correlate with urinary protein (UP). Furthermore, there are a few reports that suggested a correlation between urinary (u-) suPAR and...