Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection

Chronic infusion of angiotensin-II in atheroprone ( ApoE −/− ) mice provides a reproducible model of dissection in the suprarenal abdominal aorta, often with a false lumen and intramural thrombus that thickens the wall. Such lesions exhibit complex morphologies, with different regions characterized by localized changes in wall composition, microstructure, and properties. We sought to quantify the multiaxial mechanical properties of murine...