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Matthew R. Bersi
Yale University
AnatomyBiomedical engineeringCardiologyAortaAngiotensin II
44Publications
13H-index
486Citations
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Publications 43
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#1Matthew R. Bersi (Yale University)H-Index: 13
#2Víctor A. Acosta Santamaría (University of Lyon)
Last. Stéphane Avril (University of Lyon)H-Index: 31
view all 8 authors...
Chronic infusion of angiotensin-II in atheroprone (ApoE−/−) mice provides a reproducible model of dissection in the suprarenal abdominal aorta, often with a false lumen and intramural thrombus that thickens the wall. Such lesions exhibit complex morphologies, with different regions characterized by localized changes in wall composition, microstructure, and properties. We sought to quantify the multiaxial mechanical properties of murine dissecting aneurysm samples by combining in vitro extension-...
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#1Bart Spronck (UM: Maastricht University)H-Index: 9
#2Marcos Latorre Ferrus (Yale University)H-Index: 13
Last. Mo Wang (Yale University)H-Index: 1
view all 13 authors...
Objective: Many genetically-induced mutations affect aortic structure and function in mice, but little is known about the influence of background strain. This study quantifies the aortic phenotype in angiotensin II (AngII)-induced hypertension across different strains of wild-type mice. Approach and Results: Adult male C57BL/6J and 129SvEv mice were studied before and after induction of hypertension via subcutaneous infusion of AngII (1000 ng/kg/min) for two weeks, which elevated blood pressure ...
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#1Nilay Taneja (Vandy: Vanderbilt University)H-Index: 5
#2Matthew R. Bersi (Vandy: Vanderbilt University)H-Index: 13
Last. Dylan T. Burnette (Vandy: Vanderbilt University)H-Index: 17
view all 9 authors...
The mechanical properties of the actin cortex regulate shape changes during cell division, cell migration, and tissue morphogenesis. We show that modulation of myosin II (MII) filament composition allows tuning of surface tension at the cortex to maintain cell shape during cytokinesis. Our results reveal that MIIA generates cortex tension, while MIIB acts as a stabilizing motor and its inclusion in MII hetero-filaments reduces cortex tension. Tension generation by MIIA drives faster cleavage fur...
1 CitationsSource
#1Guangxin Li (Yale University)H-Index: 11
#2Mo Wang (Yale University)H-Index: 1
Last. Yang Jiao (Yale University)H-Index: 5
view all 23 authors...
Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic aortic aneurysm and dissection (TAAD) because loss of medial cells associates with advanced disease. We investigated effects of SMC proliferation in the aortic media by conditional disruption of Tsc1, which hyperactivates mTOR complex 1. Consequent SMC hyperplasia led to progressive medial degeneration and TAAD. In addition to diminished contractile and synthetic functions, fate-mapped SMCs displayed inc...
2 CitationsSource
#1Lydia Aslanidou (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 6
#2Mauro Ferraro (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 3
Last. Nikolaos Stergiopulos (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 49
view all 8 authors...
Animal models of aortic aneurysm and dissection can enhance our limited understanding of the etiology of these lethal conditions particularly because early-stage longitudinal data are scant in humans. Yet, the pathogenesis of often-studied mouse models and the potential contribution of aortic biomechanics therein remain elusive. In this work, we combined micro-CT and synchrotron-based imaging with computational biomechanics to estimate in vivo aortic strains in the abdominal aorta of angiotensin...
2 CitationsSource
#1Michael A. Raddatz (Vandy: Vanderbilt University)H-Index: 2
#2Tessa Huffstater (Vandy: Vanderbilt University)
Last. Meena S. Madhur (Vandy: Vanderbilt University)H-Index: 21
view all 11 authors...
OBJECTIVE: Macrophages have been described in calcific aortic valve disease, but it is unclear if they promote or counteract calcification. We aimed to determine how macrophages are involved in calcification using the Notch1(+/-) model of calcific aortic valve disease. Approach and Results: Macrophages in wild-type and Notch1(+/-) murine aortic valves were characterized by flow cytometry. Macrophages in Notch1(+/-) aortic valves had increased expression of MHCII (major histocompatibility complex...
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#1Michael A. Raddatz (Vandy: Vanderbilt University)H-Index: 2
#2Tessa Huffstater (Vandy: Vanderbilt University)
Last. Meena S. Madhur (Vandy: Vanderbilt University)H-Index: 21
view all 11 authors...
Objective Macrophages have been described in calcific aortic valve disease, but it is unclear if they promote or counteract calcification. We aimed to determine how macrophages are involved in calcification using the Notch1+/- model of calcific aortic valve disease. Approach and Results Macrophages in wild-type and Notch1+/- murine aortic valves were characterized by flow cytometry. Macrophages in Notch1+/- aortic valves had increased expression of MHCII. We then used bone marrow transplants to ...
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#1William D. Meador (University of Texas at Austin)H-Index: 4
#2Mrudang Mathur (University of Texas at Austin)H-Index: 3
Last. Manuel K. Rausch (University of Texas at Austin)H-Index: 17
view all 8 authors...
Abstract The tricuspid valve ensures unidirectional blood flow from the right atrium to the right ventricle. The three tricuspid leaflets operate within a dynamic stress environment of shear, bending, tensile, and compressive forces, which is cyclically repeated nearly three billion times in a lifetime. Ostensibly, the microstructural and mechanical properties of the tricuspid leaflets have mechanobiologically evolved to optimally support their function under those forces. Yet, how the tricuspid...
3 CitationsSource
#1William D. Meador (University of Texas at Austin)H-Index: 4
#2Gabriella P. Sugerman (University of Texas at Austin)H-Index: 2
Last. Manuel K. Rausch (University of Texas at Austin)H-Index: 17
view all 7 authors...
Abstract Skin fulfills several vital functions, many of which are dependent on its mechanical properties. Therefore, as mice have become an invaluable model for skin research, determining murine skin's mechanical properties is important. Specifically, skin's mechanical properties are important for functional tests as well as for prognostic and diagnostic purposes. Additionally, computational simulations of skin behavior are becoming commonplace, rendering accurate models of murine skin's constit...
3 CitationsSource
#1Alison K. SchroerH-Index: 4
#2Matthew R. BersiH-Index: 13
Last. W. David MerrymanH-Index: 26
view all 10 authors...
Over one million Americans experience myocardial infarction (MI) annually, and the resulting scar and subsequent cardiac fibrosis gives rise to heart failure. A specialized cell-cell adhesion protein, cadherin-11 (CDH11), contributes to inflammation and fibrosis in rheumatoid arthritis, pulmonary fibrosis, and aortic valve calcification but has not been studied in myocardium after MI. MI was induced by ligation of the left anterior descending artery in mice with either heterozygous or homozygous...
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