Original paper
Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress
Abstract
Human skin tolerates a surprisingly high burden of oncogenic lesions. Although adult epidermis can suppress the expansion of individual mutant clones, the mechanisms behind tolerance to oncogene activation across broader regions of tissue are unclear. Here, we uncover a dynamic translational mechanism that coordinates oncogenic HRAS-induced hyperproliferation with loss of progenitor self-renewal to restrain aberrant growth and tumorigenesis. We...
Paper Details
Title
Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress
Published Date
Aug 1, 2020
Journal
Volume
27
Issue
2
Pages
270 - 283.e7
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Notes
History