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Cell Stem Cell
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21.46
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Papers 2418
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#1Yishai Avior (HUJI: Hebrew University of Jerusalem)H-Index: 6
#2Kevin Eggan (Broad Institute)H-Index: 52
Last.Nissim Benvenisty (HUJI: Hebrew University of Jerusalem)H-Index: 59
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Human pluripotent stem cells (hPSCs) are known to harbor chromosomal aberrations, affecting their tumorigenic potential. We established a strategy to identify cancer-related point mutations in hPSCs, detecting recurrent mutations in over 20 genes, alongside those previously detected in p53. Importantly, naive hPSCs harbor, on average, four times more mutations than their primed counterparts, which appear primarily in pathways inhibited during naive conversion. Such cancer-related mutations shoul...
#1Lizhi Leng (CSU: Central South University)H-Index: 2
#2Jiya Sun (Peking Union Medical College)
Last.Yonglun LuoH-Index: 14
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Summary To investigate the contribution of parental genomes to early embryogenesis, we profiled the single-cell transcriptomes of human biparental and uniparental embryos systematically from the 1-cell to the morula stage. We observed that uniparental embryos exhibited variable and decreased embryonic genome activation (EGA). Comparative transcriptome analysis identified 807 maternally biased expressed genes (MBGs) and 581 paternally biased expressed genes (PBGs) in the preimplantation stages. M...
#1Stephanie Xie (Princess Margaret Cancer Centre)H-Index: 10
#2Laura García-Prat (Princess Margaret Cancer Centre)H-Index: 7
Last.Ishita Patel (Princess Margaret Cancer Centre)
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Summary Cellular stress responses serve as crucial decision points balancing persistence or culling of hematopoietic stem cells (HSCs) for lifelong blood production. Although strong stressors cull HSCs, the linkage between stress programs and self-renewal properties that underlie human HSC maintenance remains unknown, particularly at quiescence exit when HSCs must also dynamically shift metabolic state. Here, we demonstrate distinct wiring of the sphingolipidome across the human hematopoietic hi...
#1Markus Riessland (Rockefeller University)H-Index: 17
#2Benjamin Kolisnyk (Rockefeller University)H-Index: 7
Last.Lavoisier Ramos-Espiritu (Rockefeller University)H-Index: 6
view all 17 authors...
Summary Cellular senescence is a mechanism used by mitotic cells to prevent uncontrolled cell division. As senescent cells persist in tissues, they cause local inflammation and are harmful to surrounding cells, contributing to aging. Generally, neurodegenerative diseases, such as Parkinson’s, are disorders of aging. The contribution of cellular senescence to neurodegeneration is still unclear. SATB1 is a DNA binding protein associated with Parkinson’s disease. We report that SATB1 prevents cellu...
#1Nicolas Severe (Harvard University)H-Index: 11
#2Nezihi Murat Karabacak (Harvard University)H-Index: 9
Last.Elizabeth Scadden (Harvard University)
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Summary Stromal cell populations that maintain hematopoietic stem and progenitor cells (HSPCs) are generally characterized in steady-state conditions. Here, we report a comprehensive atlas of bone marrow stromal cell subpopulations under homeostatic and stress conditions using mass cytometry (CyTOF)-based single-cell protein analysis. We identified 28 subsets of non-hematopoietic cells during homeostasis, 14 of which expressed hematopoietic regulatory factors. Irradiation-based conditioning for ...
#1H. Isaac Chen (UPenn: University of Pennsylvania)H-Index: 15
#2John A. Wolf (UPenn: University of Pennsylvania)H-Index: 21
Last.Hongjun SongH-Index: 67
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Recent demonstrations of human brain organoid transplantation in rodents have accentuated ethical concerns associated with these entities, especially as they relate to potential “humanization” of host animals. Consideration of established scientific principles can help define the realistic range of expected outcomes in such transplantation studies. This practical approach suggests that augmentation of discrete brain functions in transplant hosts is a more relevant ethical question in the near te...
#1Justin Rustenhoven (UVA: University of Virginia)
#2Jonathan Kipnis (UVA: University of Virginia)H-Index: 53
Neurogenesis is critical to continuously replacie olfactory neurons but is impaired during chronic inflammatory rhinosinusitis. In this issue of Cell Stem Cell, Chen et al. (2019) describe the inflammation-induced switching of olfactory stem cells from a regenerative phenotype to one participating in immune defense; this process contributes to deficient replacement of olfactory sensory neurons.
#1Mengfei Chen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
#2Randall R. Reed (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 52
Last.Andrew P. Lane (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 28
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Summary Although olfactory mucosa possesses long-lived horizontal basal stem cells (HBCs) and remarkable regenerative capacity, the function of human olfactory neuroepithelium is significantly impaired in chronic inflammatory rhinosinusitis. Here, we show that, while inflammation initially damages olfactory neurons and activates HBC-mediated regeneration, continued inflammation locks HBCs in an undifferentiated state. Global gene expression in mouse HBCs reveals broad upregulation of NF-κB-regul...
#1Yanni Zhu (UCLA: University of California, Los Angeles)H-Index: 1
#2Drake Smith (UCLA: University of California, Los Angeles)H-Index: 2
Last.Christian Hardoy (UCLA: University of California, Los Angeles)
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Summary Invariant natural killer T (iNKT) cells are potent immune cells for targeting cancer; however, their clinical application has been hindered by their low numbers in cancer patients. Here, we developed a proof-of-concept for hematopoietic stem cell-engineered iNKT (HSC-iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient’s lifetime. Using a human HSC engrafted mouse model and a human iNKT TCR gene engineering approach, we demonstrated the efficien...
#1Bruno Di StefanoH-Index: 13
#2EnChing Luo (UCSD: University of California, San Diego)
Last.Aaron J. HuebnerH-Index: 9
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Summary Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored. Here, we show that suppression of the RNA helicase DDX6 endows human and mouse primed embryonic stem cells (ESCs) with a differentiation-resistant, “hyper-pluripotent” state, which readily reprograms to a naive state resembling the preimplantation embryo. We further demonstrate that DDX6 plays a key role in adult progenito...
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