Cell Stem Cell
Papers 2536
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#1Samik Upadhaya (NYU: New York University)H-Index: 3
#2Oleg Krichevsky (BGU: Ben-Gurion University of the Negev)H-Index: 19
Last. Boris Reizis (NYU: New York University)H-Index: 49
view all 6 authors...
Summary Adult mammalian hematopoietic stem cells (HSCs) reside in the bone marrow (BM) but can be mobilized into blood for use in transplantation. HSCs interact with BM niche cells that produce growth factor c-Kit ligand (Kitl/SCF) and chemokine CXCL12, and were thought to be static and sessile. We used two-photon laser scanning microscopy to visualize genetically labeled HSCs in the BM of live mice for several hours. The majority of HSCs showed a dynamic non-spherical morphology and significant...
#1Liuliu Yang (Cornell University)H-Index: 2
#2Yuling Han (Cornell University)H-Index: 2
Last. Fabrice Jaffré (Cornell University)H-Index: 8
view all 37 authors...
Summary SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. We present an experimental platform comprised of cell and organoid derivatives from human pluripotent stem cells (hPSCs). A Spike-enabled pseudo-entry virus infects pancreatic endocrine cells, liver org...
2 CitationsSource
#1Leyun Wang (CAS: Chinese Academy of Sciences)H-Index: 7
#2Zhikun Li (CAS: Chinese Academy of Sciences)H-Index: 7
Last. Hu Nie (CAS: Chinese Academy of Sciences)
view all 18 authors...
Summary Successful cloning by somatic cell nuclear transfer (SCNT) requires overcoming significant epigenetic barriers. Genomic imprinting is not generally regarded as such a barrier, although H3K27me3-dependent imprinting is differentially distributed in E6.5 epiblast and extraembryonic tissues. Here we report significant enhancement of SCNT efficiency by deriving somatic donor cells carrying simultaneous monoallelic deletion of four H3K27me3-imprinted genes from haploid mouse embryonic stem ce...
#1Huang Zhu (UCSD: University of California, San Diego)H-Index: 6
#2Robert Blum (UCSD: University of California, San Diego)H-Index: 4
Last. Karl-Johan Malmberg (Oslo University Hospital)H-Index: 40
view all 11 authors...
Summary Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key negative regulator of interleukin-15 (IL-15) signaling in natural killer (NK) cells. Here, we develop human CISH-knockout (CISH−/−) NK cells using an induced pluripotent stem cell-derived NK cell (iPSC-NK cell) platform. CISH−/− iPSC-NK cells demonstrate increased IL-15-mediated JAK-STAT signaling activity. Consequently, CISH−/− iPSC-NK cells exhibit improved expansion and increased cytotoxic activity agai...
#1Elise Y. Cai (UW: University of Washington)
#2Megan Kufeld (Fred Hutchinson Cancer Research Center)H-Index: 1
Last. Slobodan Beronja (Fred Hutchinson Cancer Research Center)H-Index: 14
view all 8 authors...
Summary Human skin tolerates a surprisingly high burden of oncogenic lesions. Although adult epidermis can suppress the expansion of individual mutant clones, the mechanisms behind tolerance to oncogene activation across broader regions of tissue are unclear. Here, we uncover a dynamic translational mechanism that coordinates oncogenic HRAS-induced hyperproliferation with loss of progenitor self-renewal to restrain aberrant growth and tumorigenesis. We identify translation initiator eIF2B5 as a ...
#1David Merrick (UPenn: University of Pennsylvania)H-Index: 1
#2Patrick Seale (UPenn: University of Pennsylvania)H-Index: 45
In this issue of Cell Stem Cell, Shook et al. (2020) reveal that dermal adipocytes regulate skin wound repair via release of fatty acids that promote macrophage recruitment and accelerated revascularization. Furthermore, mature dermal adipocytes dedifferentiate into migratory extracellularmatrix-producing myofibroblasts.
#1Salvador Aznar Benitah (Catalan Institution for Research and Advanced Studies)H-Index: 30
#2Patrick-Simon WelzH-Index: 3
The circadian clock temporally organizes cellular physiology throughout the day, allowing daily environmental changes to be anticipated and potentially harmful physiologic processes to be temporally separated. By synchronizing all cells at the tissue level, the circadian clock ensures coherent temporal organismal physiology. Recent advances in our understanding of adult stem cell physiology suggest that aging and perturbations in circadian rhythmicity in stem cells are tightly intertwined. Here ...
#1Grace Hui Ting Yeo (MIT: Massachusetts Institute of Technology)
#2Lin Lin (Brigham and Women's Hospital)
Last. Richard I. Sherwood (Brigham and Women's Hospital)H-Index: 22
view all 6 authors...
Summary Empirical optimization of stem cell differentiation protocols is time consuming, is laborintensive, and typically does not comprehensively interrogate all relevant signaling pathways. Here we describe barcodelet single-cell RNA sequencing (barRNA-seq), which enables systematic exploration of cellular perturbations by tagging individual cells with RNA “barcodelets” to identify them on the basis of the treatments they receive. We apply barRNA-seq to simultaneously manipulate up to seven de...
#1Parvez Vora (McMaster University)H-Index: 10
#2Chitra Venugopal (McMaster University)H-Index: 12
Last. Nicholas C. Wong (McMaster University)H-Index: 25
view all 28 authors...
Summary CD133 marks self-renewing cancer stem cells (CSCs) in a variety of solid tumors, and CD133+ tumor-initiating cells are known markers of chemo- and radio-resistance in multiple aggressive cancers, including glioblastoma (GBM), that may drive intra-tumoral heterogeneity. Here, we report three immunotherapeutic modalities based on a human anti-CD133 antibody fragment that targets a unique epitope present in glycosylated and non-glycosylated CD133 and studied their effects on targeting CD133...
1 CitationsSource
Top fields of study
Induced pluripotent stem cell
Stem cell
Cell biology