Cell Stem Cell
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Published on Jan 1, 2019in Cell Stem Cell 23.29
Marc Thier6
Estimated H-index: 6
(German Cancer Research Center),
Oliver Hommerding1
Estimated H-index: 1
(University of Bonn)
+ 16 AuthorsAdriana Przybylla2
Estimated H-index: 2
(German Cancer Research Center)
Summary We report the direct reprogramming of both adult human fibroblasts and blood cells into induced neural plate border stem cells (iNBSCs) by ectopic expression of four neural transcription factors. Self-renewing, clonal iNBSCs can be robustly expanded in defined media while retaining multilineage differentiation potential. They generate functional cell types of neural crest and CNS lineages and could be used to model a human pain syndrome via gene editing of SCN9A in iNBSCs. NBSCs can also...
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Published on Feb 1, 2019in Cell Stem Cell 23.29
Matthew J. Carr2
Estimated H-index: 2
(University of Toronto),
Jeremy S. Toma3
Estimated H-index: 3
+ 6 AuthorsMiller Freda69
Estimated H-index: 69
Summary Peripheral innervation plays an important role in regulating tissue repair and regeneration. Here we provide evidence that injured peripheral nerves provide a reservoir of mesenchymal precursor cells that can directly contribute to murine digit tip regeneration and skin repair. In particular, using single-cell RNA sequencing and lineage tracing, we identify transcriptionally distinct mesenchymal cell populations within the control and injured adult nerve, including neural crest-derived c...
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Published on Mar 1, 2019in Cell Stem Cell 23.29
Stefano Comazzetto1
Estimated H-index: 1
(University of Texas Southwestern Medical Center),
Malea M. Murphy5
Estimated H-index: 5
(University of Texas Southwestern Medical Center)
+ 3 AuthorsSean J. Morrison77
Estimated H-index: 77
(University of Texas Southwestern Medical Center)
Summary Hematopoietic stem cells (HSCs) are maintained in a perivascular niche in bone marrow, in which leptin receptor + (LepR) stromal cells and endothelial cells synthesize factors required for HSC maintenance, including stem cell factor (SCF) . An important question is why LepR + cells are one hundred times more frequent than HSCs. Here, we show that SCF from LepR + cells is also necessary to maintain many c-kit + -restricted hematopoietic progenitors. Conditional deletion of Scf from LepR +...
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Published on Mar 1, 2019in Cell Stem Cell 23.29
Fang Ni (Emory University), Wen-Mei Yu (Emory University)+ 8 AuthorsDavid T. Scadden98
Estimated H-index: 98
(Harvard University)
Summary Hematopoietic stem cell (HSC) quiescence is a tightly regulated process crucial for hematopoietic regeneration, which requires a healthy and supportive microenvironmental niche within the bone marrow (BM). Here, we show that deletion of Ptpn21 , a protein tyrosine phosphatase highly expressed in HSCs, induces stem cell egress from the niche due to impaired retention within the BM. Ptpn21 −/− HSCs exhibit enhanced mobility, decreased quiescence, increased apoptosis, and defective reconsti...
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Published on Jan 1, 2019in Cell Stem Cell 23.29
Briana C. Prager9
Estimated H-index: 9
(University of California, San Diego),
Qi Xie14
Estimated H-index: 14
(University of California, San Diego)
+ 1 AuthorsJeremy N. Rich79
Estimated H-index: 79
(University of California, San Diego)
Summary Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a supportive niche. Viewed through the lens of an ecosystem, numerous tumor components have multi-directional interactions involving CSCs, supporting the complexity of tumors to maintain growth in a dynamic host. In this Perspective, we discuss how CSCs are active architects of their microenvironment and drive interactions with other tumor components, such as immune cells, cancer-associated fibroblasts and di...
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Published on Feb 1, 2019in Cell Stem Cell 23.29
Asaf Zviran6
Estimated H-index: 6
(Weizmann Institute of Science),
Nofar Mor3
Estimated H-index: 3
(Weizmann Institute of Science)
+ 33 AuthorsLeehee Weinberger8
Estimated H-index: 8
(Weizmann Institute of Science)
Summary The epigenetic dynamics of induced pluripotent stem cell (iPSC) reprogramming in correctly reprogrammed cells at high resolution and throughout the entire process remain largely undefined. Here, we characterize conversion of mouse fibroblasts into iPSCs using Gatad2a-Mbd3/NuRD-depleted and highly efficient reprogramming systems. Unbiased high-resolution profiling of dynamic changes in levels of gene expression, chromatin engagement, DNA accessibility, and DNA methylation were obtained. W...
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Published on Feb 1, 2019in Cell Stem Cell 23.29
Stefan Frank1
Estimated H-index: 1
(University of Cologne),
Gaurav Ahuja6
Estimated H-index: 6
(University of Cologne)
+ 25 AuthorsTheodore Georgomanolis (University of Göttingen)
Summary Human protein-coding genes are often accompanied by divergently transcribed non-coding RNAs whose functions, especially in cell fate decisions, are poorly understood. Using an hESC-based cardiac differentiation model, we define a class of divergent lncRNAs, termed yin yang lncRNAs (yylncRNAs), that mirror the cell-type-specific expression pattern of their protein-coding counterparts. yylncRNAs are preferentially encoded from the genomic loci of key developmental cell fate regulators. Mos...
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Published on Jan 1, 2019in Cell Stem Cell 23.29
Yu Kitadate7
Estimated H-index: 7
(National Institute for Basic Biology, Japan),
David J. Jörg9
Estimated H-index: 9
(University of Cambridge)
+ 20 AuthorsChiharu Kimura-Yoshida13
Estimated H-index: 13
(Boston Children's Hospital)
Summary In many tissues, homeostasis is maintained by physical contact between stem cells and an anatomically defined niche. However, how stem cell homeostasis is achieved in environments where cells are motile and dispersed among their progeny remains unknown. Using murine spermatogenesis as a model, we find that spermatogenic stem cell density is tightly regulated by the supply of fibroblast growth factors (FGFs) from lymphatic endothelial cells. We propose that stem cell homeostasis is achiev...
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Published on Jan 1, 2019in Cell Stem Cell 23.29
Maëlle Givelet1
Estimated H-index: 1
,
Clémentine Lapoujade (University of Paris-Sud), Pierre Fouchet (University of Paris-Sud)
Mechanisms regulating maintenance of the stem cell pool in facultative niches of the mammalian testis are poorly understood. In this issue of Cell Stem Cell , Kitadate et al. (2019) propose a minimal model in which stem cells compete for limited resources of fibroblast growth factors, which predicts their density during homeostasis and regenerative conditions.
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