Cell Stem Cell
Papers 2389
1 page of 239 pages (2,389 results)
Published on Jan 1, 2018
Juergen Fink5
Estimated H-index: 5
Seungmin Han + 17 AuthorsAmanda Andersson-Rolf7
Estimated H-index: 7
Published in Cell Stem Cell21.46
Yorick Post2
Estimated H-index: 2
(KNAW: Royal Netherlands Academy of Arts and Sciences),
Hans Clevers162
Estimated H-index: 162
(KNAW: Royal Netherlands Academy of Arts and Sciences)
Classic studies on hematopoiesis indicate that blood cell numbers are maintained by rare, hard-wired, transplantable stem cells (SCs). Subsequent studies in other organs have implicitly assumed that all SC hierarchies follow the design of the hematopoietic system. Lineage tracing techniques have revolutionized the study of solid tissue SCs. It thus appears that key characteristics of the hematopoietic SC hierarchy (rarity of SCs, specific marker expression, quiescence, asymmetric division, and u...
Published in Cell Stem Cell21.46
Yangjian Liu1
Estimated H-index: 1
(WashU: Washington University in St. Louis),
Andrew S. Yoo16
Estimated H-index: 16
(WashU: Washington University in St. Louis)
An example of the peer review process for “Mir-17∼92 Confers Differential Vulnerability of Motor Neuron Subtypes to ALS-Associated Degeneration” ( Tung et al., 2019 ) is presented here.
Published on May 1, 2019in Cell Stem Cell21.46
Ying-Tsen Tung2
Estimated H-index: 2
(AS: Academia Sinica),
Kuan-Chih Peng1
Estimated H-index: 1
(AS: Academia Sinica)
+ 4 AuthorsJun-An Chen7
Estimated H-index: 7
(AS: Academia Sinica)
Summary Progressive degeneration of motor neurons (MNs) is the hallmark of amyotrophic lateral sclerosis (ALS). Limb-innervating lateral motor column MNs (LMC-MNs) seem to be particularly vulnerable and are among the first MNs affected in ALS. Here, we report association of this differential susceptibility with reduced expression of the mir-17∼92 cluster in LMC-MNs prior to disease onset. Reduced mir-17∼92 is accompanied by elevated nuclear PTEN in spinal MNs of presymptomatic SOD1 G93A mice. Se...
Published on Jun 1, 2019in Cell Stem Cell21.46
Benson M. George6
Estimated H-index: 6
(Stanford University),
Kevin S. Kao3
Estimated H-index: 3
(Stanford University)
+ 11 AuthorsDevon Cajuste (Stanford University)
Summary Hematopoietic cell transplantation can correct hematological and immunological disorders by replacing a diseased blood system with a healthy one, but this currently requires depleting a patient’s existing hematopoietic system with toxic and non-specific chemotherapy, radiation, or both. Here we report an antibody-based conditioning protocol with reduced toxicity and enhanced specificity for robust hematopoietic stem cell (HSC) transplantation and engraftment in recipient mice. Host pre-t...
Published in Cell Stem Cell21.46
Shiva Bamezai3
Estimated H-index: 3
(University of Ulm),
Christian Buske40
Estimated H-index: 40
(University of Ulm)
Leukemic stem cells (LSCs) in acute myeloid leukemia (AML) can drive tumor growth and relapse. In this issue of Cell Stem Cell, McKenzie et al. (2019) report that some mature leukemic cells can de-differentiate and contribute to AML tumorigenesis, a finding with important implications for therapies focused on eradicating LSCs.
Published on Jul 1, 2019in Cell Stem Cell21.46
Patricia Rusu (DKFZ: German Cancer Research Center), Chunxuan Shao (DKFZ: German Cancer Research Center)+ 21 AuthorsSteffen Dettling1
Estimated H-index: 1
(Heidelberg University)
Summary Brain tumor stem cells (BTSCs) are a chemoresistant population that can drive tumor growth and relapse, but the lack of BTSC-specific markers prevents selective targeting that spares resident stem cells. Through a ribosome-profiling analysis of mouse neural stem cells (NSCs) and BTSCs, we find glycerol-3-phosphate dehydrogenase 1 (GPD1) expression specifically in BTSCs and not in NSCs. GPD1 expression is present in the dormant BTSC population, which is enriched at tumor borders and drive...
Published on May 1, 2019in Cell Stem Cell21.46
Anaëlle Grabek (French Institute of Health and Medical Research), Bastien Dolfi (French Institute of Health and Medical Research)+ 3 AuthorsAndreas Schedl39
Estimated H-index: 39
(French Institute of Health and Medical Research)
Summary Evolution has resulted in profound differences between males and females that extend to non-reproductive organs and are reflected in the susceptibility and progression of diseases. However, the cellular and molecular basis for these differences remains largely unknown. Here we report that adrenal gland tissue renewal is highly active and sexually dimorphic, with female mice showing a 3-fold higher turnover than males. Moreover, in males, homeostasis relies on proliferation of cells withi...
Published in Cell Stem Cell21.46
Yuqing Zhu (ZJU: Zhejiang University), Jin Zhang13
Estimated H-index: 13
(ZJU: Zhejiang University)
In this issue of Cell Stem Cell, MacDougall et al. (2019) utilized a CRISPR mutagenesis screen to identify factors for mESC self-renewal and found that intracellular calcium and nuclear export act in naive pluripotency exit. Combined knockout of Tcf7l1 and the calcium transporter Atp2b1 enabled mESCs to self-renew in the absence of LIF and 2i.
Published in Cell Stem Cell21.46
Hannah T. Stuart2
Estimated H-index: 2
(University of Cambridge),
Giuliano Giuseppe Stirparo7
Estimated H-index: 7
(University of Cambridge)
+ -3 AuthorsAndrew A. Malcolm (University of Cambridge)
Summary Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are questions of wide interest. Here we show that acquisition of naive pluripotency can follow transcriptionally and mechanistically distinct routes. Starting from post-implantation epiblast stem cells (EpiSCs), one route advances through a mesodermal state prior to naive pluripotency induction, whereas another transiently resembles the early inner cell mass an...