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Cell Stem Cell
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#1Jacob Kjell (LMU: Ludwig Maximilian University of Munich)H-Index: 2
#2Judith Fischer-Sternjak (LMU: Ludwig Maximilian University of Munich)H-Index: 1
Last.Kristian Franze (University of Cambridge)H-Index: 28
view all 12 authors...
Summary The mammalian brain contains few niches for neural stem cells (NSCs) capable of generating new neurons, whereas other regions are primarily gliogenic. Here we leverage the spatial separation of the sub-ependymal zone NSC niche and the olfactory bulb, the region to which newly generated neurons from the sub-ependymal zone migrate and integrate, and present a comprehensive proteomic characterization of these regions in comparison to the cerebral cortex, which is not conducive to neurogenes...
1 CitationsSource
#1Zhe Zhu (UCSD: University of California, San Diego)H-Index: 9
#2Pinar Mesci (UCSD: University of California, San Diego)H-Index: 7
Last.Jeremy N. Rich (UCSD: University of California, San Diego)H-Index: 84
view all 34 authors...
Summary Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem cells (GSCs). Here we demonstrate that ZIKV preferentially infected and killed GSCs and stem-like cells in medulloblastoma and ependymoma in a SOX2-dependent manner. Targeting SOX2 severely attenuated ZIKV infection, in contrast to AXL. As mechanisms of SOX2-mediated ZIKV infection, we identified inverse ex...
1 CitationsSource
#1Jorge-Miguel Faustino Martins (MDC: Max Delbrück Center for Molecular Medicine)H-Index: 1
#2Cornelius Fischer (MDC: Max Delbrück Center for Molecular Medicine)H-Index: 6
Last.Mina Gouti (MDC: Max Delbrück Center for Molecular Medicine)H-Index: 11
view all 13 authors...
Summary Neuromuscular networks assemble during early human embryonic development and are essential for the control of body movement. Previous neuromuscular junction modeling efforts using human pluripotent stem cells (hPSCs) generated either spinal cord neurons or skeletal muscles in monolayer culture. Here, we use hPSC-derived axial stem cells, the building blocks of the posterior body, to simultaneously generate spinal cord neurons and skeletal muscle cells that self-organize to generate human...
1 CitationsSource
#1Bernadette A. Chua (UCSD: University of California, San Diego)H-Index: 1
#2Inge Van Der Werf (UCSD: University of California, San Diego)H-Index: 1
Last.Robert A.J. Signer (UCSD: University of California, San Diego)H-Index: 13
view all 4 authors...
Cellular identity is not driven by differences in genomic content but rather by epigenomic, transcriptomic, and proteomic heterogeneity. Although regulation of the epigenome plays a key role in shaping stem cell hierarchies, differential expression of transcripts only partially explains protein abundance. The epitranscriptome, translational control, and protein degradation have emerged as fundamental regulators of proteome complexity that regulate stem cell identity and function. Here, we discus...
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#1Jingtao Guo (UofU: University of Utah)H-Index: 2
#2X Nie (UofU: University of Utah)
Last.Bradley R. Cairns (UofU: University of Utah)H-Index: 62
view all 15 authors...
Summary The human testis undergoes dramatic developmental and structural changes during puberty, including proliferation and maturation of somatic niche cells, and the onset of spermatogenesis. To characterize this understudied process, we profiled and analyzed single-cell transcriptomes of ∼10,000 testicular cells from four boys spanning puberty and compared them to those of infants and adults. During puberty, undifferentiated spermatogonia sequentially expand and differentiate prior to the ini...
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#1Justin K. Ichida (SC: University of Southern California)H-Index: 20
#2Chien-Ping Ko (SC: University of Southern California)
Stem cell technology enables the production of three-dimensional organ-like structures, but engineering multi-tissue anatomy has proven difficult. In this issue of Cell Stem Cell, Martins et al. (2020) show that generating a common progenitor cell for posterior spinal cord and muscle enables the formation of functional neuromuscular junctions in single organoids.
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#1Johnny Kim (MPG: Max Planck Society)H-Index: 7
#2BraunThomas (MPG: Max Planck Society)H-Index: 62
Two recent papers in Cell Stem Cell by Soliman et al. (2020) and Scott et al. (2019) explore the contributions of mesenchymal progenitor cells to fibrosis in heart and skeletal muscle. They find tissue-dependent roles for a subpopulation of mesenchymal progenitors expressing Hic1 with varied differentiation capacities and pathophysiologic contributions.
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#1Hesham Soliman (Minia University)H-Index: 6
#2Ben Paylor (UBC: University of British Columbia)H-Index: 5
Last.Paola Braghetta (UNIPD: University of Padua)H-Index: 23
view all 17 authors...
Summary The cardiac stroma contains multipotent mesenchymal progenitors. However, lineage relationships within cardiac stromal cells are poorly defined. Here, we identified heart-resident PDGFRa+ SCA-1+ cells as cardiac fibro/adipogenic progenitors (cFAPs) and show that they respond to ischemic damage by generating fibrogenic cells. Pharmacological blockade of this differentiation step with an anti-fibrotic tyrosine kinase inhibitor decreases post-myocardial infarction (post-MI) remodeling and l...
1 CitationsSource
#1Jiesi Luo (Yale University)H-Index: 4
#2Lingfeng Qin (Yale University)H-Index: 21
Last.Yibing QyangH-Index: 21
view all 22 authors...
Summary Vascular smooth muscle cells (VSMCs) can be derived in large numbers from human induced pluripotent stem cells (hiPSCs) for producing tissue-engineered vascular grafts (TEVGs). However, hiPSC-derived TEVGs are hampered by low mechanical strength and significant radial dilation after implantation. Here, we report generation of hiPSC-derived TEVGs with mechanical strength comparable to native vessels used in arterial bypass grafts by utilizing biodegradable scaffolds, incremental pulsatile...
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Top fields of study
Induced pluripotent stem cell
Stem cell
Genetics
Biology
Cell biology