Association of OPRM1 Functional Coding Variant With Opioid Use Disorder

Importance

With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD).

Objectives

To detect genetic risk variants for OUD and determine genetic correlations and causal association with OUD and other traits.

Design, Setting, and Participants

A genome-wide association study of electronic health record–defined OUD in the Million Veteran Program sample...