Effect of Peripheral Insulin Administration on Phosphorylation of Tau in the Brain

Background:Abnormally hyperphosphorylated tau is the major protein of neurofibrillary tangles in Alzheimer’s disease. Insulin activates PI3K-AKT signaling and regulates tau phosphorylation. Impaired brain insulin signaling is involved in Alzheimer’s disease pathogenesis. However, the effect of peri pheral insulin on tau phosphorylation is controversial. Objective:In the present study, we determined the effect of peripheral insulin administration...