First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia
Abstract
Obstructive sleep apnea (OSA) is associated to a high prevalence of resistant arterial hypertension (HTN) justifying the research on novel targets. Chronic intermittent hypoxia (CIH) is a key feature in the development of OSA comorbidities, including HTN. We used a rat model of CIH-induced HTN to disclose the hypothesis that the aryl hydrocarbon receptor (AHR) is activated by CIH once it shares the same binding partner of HIF-1α and promotes...
Paper Details
Title
First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia
Published Date
Sep 1, 2020
Journal
Volume
159
Pages
104869 - 104869
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