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Pharmacological Research
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#1Mafalda R. Couto (University of Montpellier)
#2Pedro Gonçalves (French Institute of Health and Medical Research)H-Index: 3
Last. Fátima Martel (University of Porto)H-Index: 28
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Abstract Inflammatory bowel disease (IBD) refers to a group of heterogeneous disorders associated with chronic inflammation of the gut, having a high rate of incidence in the world. In the present review, we will discuss the link between the short-chain fatty acids, especially butyrate (BT), produced by bacterial fermentation of dietary fiber, and IBD development. Current knowledge supports an anti-inflammatory role for BT and suggests that BT insufficiency may be involved in the pathogenesis of...
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#1Kuan-Fu Liao (TCU: Tzu Chi University)H-Index: 15
#2Yu-Hung KuoH-Index: 1
Last. Shih-Wei Lai (PRC: China Medical University (PRC))H-Index: 23
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#1Vincenzo RussoH-Index: 39
#2Marco Di MaioH-Index: 5
Last. Pierpaolo Di MiccoH-Index: 15
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Abstract Little is still known about the clinical features associated with the occurrence of acute respiratory distress syndrome (ARDS) in hospitalized patients with Coronavirus disease 2019 (COVID-19). The aim of the present study was to describe the prevalence of pre-admission antithrombotic therapies in patients with COVID-19 and to investigate the potential association between antithrombotic therapy and ARDS, as disease clinical presentation, or in-hospital mortality. We enrolled 192 consecu...
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#1Simona Panelli (University of Milan)H-Index: 6
#2Sara Epis (University of Milan)H-Index: 13
Last. Gian Vincenzo Zuccotti (University of Milan)H-Index: 37
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Abstract This review tackles the concept of the evolutionary mismatch, in relation with the reduction of the prevalence of the so-called “dirty old friends”. These formed the variegated community of parasites and microorganisms, either prokaryotic or eukaryotic, that, over long evolutionary times, co-evolved with humans and their ancestors, inhabiting their digestive tracts, and other body districts. This community of microbial symbionts and metazoan parasites is thought to have evolved a comple...
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#1Yinchuan Xu (ZJU: Zhejiang University)H-Index: 14
#2Shujing Zhang (ZJU: Zhejiang University)
Last. Zhaocai Zhang (ZJU: Zhejiang University)H-Index: 5
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Abstract Sepsis induced myocardial dysfunction (SIMD) results in high morbidity and mortality. However, the effective therapeutic strategies for SIMD treatment remain limited. Sirt3 is the main mitochondrial Sirtuin member and is a key modulator of mitochondrial metabolism and function. In this study, we aimed to investigate the effect and mechanism of Sirt3 on SIMD. SIMD was induced by 20 mg/kg Lipopolysaccharides (LPS) injection for 6 h in mice. Sepsis could induce the reduction of cardiac Sir...
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#1Sida Jiang (CPU: China Pharmaceutical University)H-Index: 1
#2Qiuji Cui (CPU: China Pharmaceutical University)H-Index: 1
Last. Yu-zongCHEN (NUS: National University of Singapore)H-Index: 46
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1 CitationsSource
#1Vito Annese (United Arab Emirates University)
Abstract Inflammatory bowel diseases (IBD) are chronic intermittent inflammatory disorders of the gastrointestinal tract of unknown etiology but a clear genetic predisposition. Prompted by the first investigations on IBD families and twins, the genetic and epigenetic studies have produced an unprecedented amount of information in comparison with other immune-mediated or complex diseases. New inflammatory pathways and possible mechanisms of action have been disclosed, potentially leading to new-t...
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#1Inês Correia-Sá (University of Porto)H-Index: 5
#2Anita Paiva (University of Porto)
Last. Maria Augusta Vieira-Coelho (University of Porto)H-Index: 23
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Abstract Introduction Recently, the endocannabinoid system has been identified in skin and it has been linked with the formation of skin fibrosis and wound healing. We aimed to find and analyse reported data on compounds acting in the endocannabinoid system with significant effect in skin fibrosis. Methods A literature search on PUBMED was conducted for studies published in English until February 2020 on cannabinoids and skin fibrosis. The initial search was performed with terms: “cannabinoid” A...
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#1Delong Chen (JNU: Jinan University)
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Abstract Osteoporosis, characterized by disrupted bone resorption and formation, is viewed as a global health challenge. Arctiin (ARC) is a main component of Arctium lappa L, which exerts chemopreventive effects against various tumor cells. However, the role of ARC in bone remodeling is still unclear. Here, we first demonstrated that ARC inhibits osteoclast formation and bone resorption function induced by the receptor activator of nuclear factor-κB ligand (RANKL) in a dose- and time-dependent m...
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#1Jingjing Fan (Wuhan Sports University)
#2Ziyuan Feng (Wuhan Sports University)
Last. Ning Chen (Wuhan Sports University)
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Abstract Spermidine, as a natural component from polyamine members, is originally isolated from semen and also existed in many natural plants, and can be responsible for cell growth and development in eukaryotes. The supplementation of spermidine can extend health and lifespan across species. Although the elevated levels of polyamines and the regulation of rate-limiting enzymes for polyamine metabolism have been identified as the biomarkers in many cancers, recent epidemiological data support th...
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Endocrinology
Biochemistry
Diabetes mellitus
Biology
Pharmacology