Pharmacological Research
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4.90
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8397
Papers 8387
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Published on Jan 1, 2019in Pharmacological Research 4.90
Antonino Cattaneo50
Estimated H-index: 50
,
Simona Capsoni1
Estimated H-index: 1
(University of Ferrara)
Abstract Nerve Growth Factor (NGF) is a therapeutic candidate for Alzheimer’s disease, based on its well known actions on basal forebrain cholinergic neurons. However, because of its pro-nociceptive activity, in current clinical trials NGF has to be administered intraparenchymally into the brain by neurosurgery via cell or gene therapy approaches. To prevent the NGF pain-inducing collateral effects, thus avoiding the necessity for local brain injection, we developed painless NGF (hNGFp), based o...
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Published on Jan 1, 2019in Pharmacological Research 4.90
Matthew Hearing1
Estimated H-index: 1
(Marquette University)
Abstract In addiction, an individual’s ability to inhibit drug seeking and drug taking is thought to reflect a pathological strengthening of drug-seeking behaviors or impairments in the capacity to control maladaptive behavior. These processes are not mutually exclusive and reflect drug-induced modifications within prefrontal cortical and nucleus accumbens circuits, however unlike psychostimulants such as cocaine, far less is known about the temporal, anatomical, and cellular dynamics of these c...
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Published on Mar 1, 2019in Pharmacological Research 4.90
Rita Rezzani33
Estimated H-index: 33
(University of Brescia),
Caterina Franco (University of Brescia), Luigi Fabrizio Rodella39
Estimated H-index: 39
(University of Brescia)
Abstract Nowadays, it is known that the sex differences regard many organs, e.g., liver, vessels, pancreas, lungs, bronchi and also the brain. Sex differences are not just a matter of ethical and moral principles, as they are central to explain many still unknown diseases and their understanding is a prerequisite to develop an effective therapy for each individual. This review reports on those sex differences that are not only macroscopic and morphological, but also involve molecular and functio...
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Published on Jan 1, 2019in Pharmacological Research 4.90
Harshul Batra1
Estimated H-index: 1
(Georgia State University),
Shrikant Pawar4
Estimated H-index: 4
(Georgia State University),
Dherya Bahl1
Estimated H-index: 1
(University of Iowa)
Abstract A huge surge of research is being conducted on combination therapy with anticancer compounds formulated in the form of nanoparticles (NPs). Numerous advantages like dose minimalization and synergism, reversal of multi drug resistance (MDRs), enhanced efficacy have emerged with nanoencapsulation of chemotherapeutic agents with chemo-sensitizing agent like curcumin. Within last couple of years various nano-sized formulations have been designed and tested both in vitro with cell lines for ...
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Published on Mar 1, 2019in Pharmacological Research 4.90
Rosanna Di Paola45
Estimated H-index: 45
(University of Messina),
Roberta Fusco5
Estimated H-index: 5
(University of Messina)
+ 5 AuthorsCuzzocreaSalvatore79
Estimated H-index: 79
(Saint Louis University)
Abstract Inflammatory bowel disease is characterised by intricate immune cell interactions with tissue cells and such cross-talks can become deregulated. The formyl peptide receptor 1 (Fpr1) is expressed by both immune and stromal cells including epithelial cells. We evaluated the development of the physiopathology of the DNBS induced colitis in Fpr1 KO mice on the C57BL/6 genetic background compared to C57BL/6 genetic background animals. We have assessed both macroscopic and histological marker...
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Published on Jan 1, 2019in Pharmacological Research 4.90
V. Corpas-López6
Estimated H-index: 6
(University of Granada),
Mónica Díaz-Gavilán10
Estimated H-index: 10
(University of Granada)
+ 9 AuthorsJosé A. Gómez-Vidal9
Estimated H-index: 9
(University of Granada)
Abstract There is currently no satisfactory treatment for visceral leishmaniasis; the disease is thus in desperate need of novel drugs. The ideal candidate should be effective, safe, affordable, and administered via the oral route. Histone deacetylases (HDACs) are involved in silencing critical regulatory pathways, including pro-apoptotic programs, and represent potential therapeutic targets for pharmacological interventions. O -alkyl hydroxamates have traditionally been considered to exert no e...
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Published on Mar 1, 2019in Pharmacological Research 4.90
Maryam Baeeri20
Estimated H-index: 20
(Tehran University of Medical Sciences),
Haji Bahadar1
Estimated H-index: 1
(Khyber Medical University)
+ 5 AuthorsMohammad Abdollahi64
Estimated H-index: 64
(Tehran University of Medical Sciences)
Abstract Senescence is a process characterized by an irreversible growth arrest in cells and induced by oxidative stress. In the current study, anti-aging potential of a well-known antioxidant, α-lipoic acid (α-LA), in rat embryonic fibroblast (REF) cells was assessed. In this regard, oxidative stress, inflammation, and apoptosis pathways were investigated on REF cells exposed to H 2 O 2 as a senescence inducer and α-LA as a protective compound. In cells treated with α-LA and H 2 O 2, level of β...
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Published on Feb 1, 2019in Pharmacological Research 4.90
Valentina R. Garbarino3
Estimated H-index: 3
(University of Texas Health Science Center at San Antonio),
Taylor A. Santos (University of Texas Health Science Center at San Antonio)+ 5 AuthorsGeorgianna G. Gould24
Estimated H-index: 24
(University of Texas Health Science Center at San Antonio)
Abstract Poorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns regarding gestational metformin use remain, as its long-term effects in offspring are unclear. In light of beneficial findings with metformin for adult mouse social behavior, we hypothesized gestational metformin treatment might also promot...
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Published on Mar 1, 2019in Pharmacological Research 4.90
Reza Tabrizi6
Estimated H-index: 6
(Shiraz University of Medical Sciences),
Omid Reza Tamtaji5
Estimated H-index: 5
(Kashan University of Medical Sciences)
+ 7 AuthorsZatollah Asemi26
Estimated H-index: 26
(Kashan University of Medical Sciences)
Current evidence suggests that statin use decreases the incidence of cardiovascular diseases (CVD) through reducing LDL cholesterol and decreasing inflammation. Metabolic syndrome (MetS) is usually associated with increased inflammatory markers and increased risk of CVD. We conducted a systematic review and meta-analysis to determine the effect of statin use on inflammatory markers including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1 (IL-1) ...
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