Match!
Pharmacological Research
IF
5.57
Papers
8472
Papers 8578
1 page of 858 pages (8,578 results)
Newest
#1Fabiola Atzeni (UNIME: University of Messina)H-Index: 47
#2Valeria Nucera (UNIME: University of Messina)H-Index: 1
Last.Gianluca Bonitta (University of Milan)H-Index: 7
view all 5 authors...
ABSTRACT Interleukin 6 (IL-6) is a pleiotropic cytokine that plays a role in the neuroendocrine system, insulin resistance, lipid metabolism, vascular disease, mitochondrial activities, neuropsychological behaviour, and also mediates communications between the immune and central nervous system (CNS). Treatment with anti-IL-6 or anti-IL-6R agents seems to alleviate allodynia and hyperalgesia, so it may be a valid option when treating the many conditions involving pathological pain as rheumatoid a...
#1Stefano AliverniniH-Index: 16
#2Barbara TolussoH-Index: 22
Last.Elisa GremeseH-Index: 25
view all 0 authors...
Abstract In the last years, a dramatic amount of research has been performed increasing the knowledge about the biological mechanism underpinning Rheumatoid Arthritis (RA) inflammation, putting B lymphocytes in the center of RA pathogenesis. Nowadays, B cell phenotypes and autoantibodies positivity arose as important biomarkers in early and long-standing disease. Moreover, comparative analysis of peripheral blood and synovial tissue compartments enables the identification of novel physiopatholog...
#1Feng Sun (AAU: Anhui Agricultural University)
#2Jiajia Wang (AAU: Anhui Agricultural University)H-Index: 1
Last.Zhang J (AAU: Anhui Agricultural University)H-Index: 63
view all 0 authors...
Abstract Selenium, at high-dose levels approaching its toxicity, protects tissues from dose-limiting toxicities of many cancer chemotherapeutics without compromising their therapeutic effects on tumors, there by allowing the delivery of higher chemotherapeutic doses to achieve increased cure rate. In this regard, selenium nanoparticles (SeNPs), which show the lowest toxicity among extensively investigated selenium compounds including methylselenocysteine and selenomethionine, are more promising ...
#1Gerwyn MorrisH-Index: 20
#2Basant K. PuriH-Index: 38
Last.Michael BerkH-Index: 88
view all 8 authors...
Abstract Myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS) is a common and disabling condition with a paucity of effective and evidence-based therapies, reflecting a major unmet need. Cognitive behavioural therapy and graded exercise are of modest benefit for only some ME/CFS patients, and many sufferers report aggravation of symptoms of fatigue with exercise. The presence of a multiplicity of pathophysiological abnormalities in at least the subgroup of people with ME/CFS diagnose...
#1Weijia Wu (Fudan University)
#2Zhijia Tang (Fudan University)
Last.Yuan Gao (Fudan University)
view all 4 authors...
Abstract In China, child and adolescent pediatricians often face challenges in treating children with the appropriate medications. Within the last 8 years, the Chinese government has already initiated a series of policies to promote development of age-appropriate medicines for children. In this study, we introduced the current status of pediatric drugs, obstacles for pediatric drugs development and regulatory reforms in China. The lack of label information in drugs for children, inadequacy of ag...
Abstract Registries characterize the effectiveness and safety of therapeutic interventions in daily clinical practice. Data from registries enable mining the records of tens of thousands of patients towards determining the effectiveness, safety, and cost-benefit of any given therapeutic. The strengths of registries include real-life settings, greater power than clinical trials to detect rare events, and the study of multiple outcomes and several research questions. Registries also have their wea...
#1Qining Yang (Dalian Medical University)H-Index: 2
#2Changyuan Wang (Dalian Medical University)H-Index: 20
Last.Huijun Sun (Dalian Medical University)H-Index: 18
view all 8 authors...
Abstract Atherosclerosis (AS) is one of the major causes leading to mortality of dysfunctional cardiovascular events in the menopausal women, which has long-term deficiency of estrogen. At present, the primary treatment for postmenopausal AS is hormone replacement therapy (HRT). However, it can increase the risks of ovarian and uterine cancers with long-term therapy. So seeking for a phytoestrogen which can overcome the disadvantages of HRT is a great mission. Dioscin, a traditional Chinese medi...
#1Joseph Hardie (UMass: University of Massachusetts Amherst)H-Index: 6
#2Javier A. Mas-Rosario (UMass: University of Massachusetts Amherst)
Last.Michelle E. Farkas (UMass: University of Massachusetts Amherst)H-Index: 14
view all 5 authors...
Abstract Immunotherapy has become a promising new approach for cancer treatment due to the immune system’s ability to remove tumors in a safe and specific manner. Many tumors express anti-inflammatory factors that deactivate the local immune response or recruit peripheral macrophages into pro-tumor roles. Because of this, effective and specific ways of activating macrophages into anti-tumor phenotypes is highly desirable for immunotherapy purposes. Here, the use of a small molecule TLR agonist a...
#1Teresa Vezza (UGR: University of Granada)H-Index: 7
Last.David Arráez-Román (UGR: University of Granada)H-Index: 27
view all 0 authors...
Abstract Introduction Many studies have showed the beneficial effects of the olive (Olea europaea) leaf extract (OLE) in experimental models of metabolic syndrome, which have been ascribed to the presence of phenolic compounds, like oleuropeoside. This study evaluated the effects of a chemically characterized OLE in high fat diet (HFD)-induced obesity in mice, describing the underlying mechanisms involved in the beneficial effects, with special attention to vascular dysfunction and gut microbiot...
12345678910