Bio-inspired apatite particles limit skin penetration of drugs for dermatology applications
Abstract
Most treatments of skin pathologies involve local administration of active agents. One issue can however be the partial transcutaneous diffusion of the drug to blood circulation, leading to undesirable effects. In this work, the original use of submicron mineral particles based on bio-inspired calcium phosphate apatite was explored for the first time as drug carriers for favoring topical delivery. The permeation of a model drug across synthetic...
Paper Details
Title
Bio-inspired apatite particles limit skin penetration of drugs for dermatology applications
Published Date
Jul 1, 2020
Journal
Volume
111
Pages
418 - 428
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History