Reward Network Glutamate Level is Associated With Dimensional Reward Responsiveness

Low reward responsiveness (RR) is prevalent in numerous psychiatric disorders, including major depression and schizophrenia, and is a predictor of treatment resistance. Functional MRI studies investigating the neural bases of RR report associations between lower RR and lower activity within, and decreased functional connectivity between, regions of the brain’s reward network. Nonetheless, the neurobiological mechanisms that give rise to reward...