Revving the CAR – Combination strategies to enhance CAR T cell effectiveness
Abstract
Chimeric antigen receptor (CAR) T cell therapy is currently approved for treatment of refractory B-cell malignancies. Response rates in these diseases are impressive by historical standards, but most patients do not have a durable response and there remains room for improvement. To date, CAR T cell activity has been even more limited in solid malignancies. These limitations are thought to be due to several pathways of resistance to CAR T cells,...
Paper Details
Title
Revving the CAR – Combination strategies to enhance CAR T cell effectiveness
Published Date
Jan 1, 2021
Journal
Volume
45
Pages
100695 - 100695
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Notes
History