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Blood Reviews
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Papers 1352
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#1Joe Lee (University of Cambridge)
#2Anna L. Godfrey (Cambridge University Hospitals NHS Foundation Trust)H-Index: 14
Last. Jyoti NangaliaH-Index: 2
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Abstract The myeloproliferative neoplasms (MPN) polycythaemia vera, essential thrombocythaemia and primary myelofibrosis are chronic myeloid disorders associated most often with mutations in JAK2, MPL and CALR, and in some patients with additional acquired genomic lesions. Whilst the molecular mechanisms downstream of these mutations are now clearer, it is apparent that clinical phenotype in the MPN is a product of complex interactions, acting between individual mutations, between disease subclo...
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#1James T. England (UBC: University of British Columbia)
#2Alym H. Abdulla (UBC: University of British Columbia)H-Index: 1
Last. Kamran Shojania (UBC: University of British Columbia)H-Index: 10
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Abstract A subset of patients with severe COVID-19 develop profound inflammation and multi-organ dysfunction consistent with a “Cytokine Storm Syndrome” (CSS). In this review we compare the clinical features, diagnosis, and pathogenesis of COVID-CSS with other hematological CSS, namely secondary hemophagocytic lymphohistiocytosis (sHLH), idiopathic multicentric Castleman disease (iMCD), and CAR-T cell therapy associated Cytokine Release Syndrome (CRS). Novel therapeutics targeting cytokines or i...
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#1Claire Fritz (Case Western Reserve University)H-Index: 1
#2Scott PortwoodH-Index: 4
Last. Eunice S. WangH-Index: 26
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Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors, which induce synthetic lethality of BRCA mutant breast and ovarian cancers, are now under active exploration for treatment of acute leukemias, specifically acute myeloid leukemia (AML). Experimental data has revealed that DNA repair deficiencies similar to those found in BRCA mutant solid tumors function in malignant hematopoietic cells to enhance cell survival and promote therapy resistance. Preclinical studies have demonstrated that inhi...
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#1Rajat Bansal (Columbia University)
#2Ran Reshef (Columbia University)H-Index: 21
Abstract Chimeric antigen receptor (CAR) T cell therapy is currently approved for treatment of refractory B-cell malignancies. Response rates in these diseases are impressive by historical standards, but most patients do not have a durable response and there remains room for improvement. To date, CAR T cell activity has been even more limited in solid malignancies. These limitations are thought to be due to several pathways of resistance to CAR T cells, including cell-intrinsic mechanisms and th...
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#1Elisabeth Karsten (RNSH: Royal North Shore Hospital)H-Index: 1
#2Benjamin R. Herbert (RNSH: Royal North Shore Hospital)H-Index: 1
Abstract For many years red blood cells have been described as inert bystanders rather than participants in intercellular signalling, immune function, or inflammatory processes. However, studies are now reporting that red blood cells from healthy individuals regulate immune cell activity and maturation, and red blood cells from disease cohorts are dysfunctional. These cells have now been shown to bind more than 50 cytokines and have been described as a sink for these molecules, and the loss of t...
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#1F. Zaja (DSM)
#2Monica CarpenedoH-Index: 9
Last. Potito Rosario Scalzulli (Casa Sollievo della Sofferenza)H-Index: 17
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Abstract Thrombopoietin receptor agonists (TPO-RAs) are currently indicated for continuous treatment of chronic primary immune thrombocytopenia (ITP). However, there is growing evidence that TPO-RAs can also trigger sustained response in 10–30% of cases after treatment tapering and discontinuation. Therefore, at least for selected responding patients, it might be rational to plan TPO-RA interruption to exploit off-treatment response. Intriguingly, complete or partial responses with TPO-RAs are f...
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Abstract In patients with hemophilia, levels of uCTX-II and sCS846 increase 5 days after joint hemorrhage with respect to the initial value. In other words, in patients with established hemophilic arthropathy, the aforesaid biomarker of joint tissue damage augments shortly after the first joint hemorrhage. In patients with hemophilia treated on demand, a correlation has been found between magnetic resonance imaging scores and the CS846 biomarker. Patients with hemophilia having more than one joi...
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#1Mohammad-Hossein Haddadi (Tehran University of Medical Sciences)
#2Ensiyeh Hajizadeh-Saffar (Royan Institute)H-Index: 5
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
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Abstract Chimeric immune receptors (CIRs) are functionally pleiotropic because they are artificially expressed on diverse cell types, which gives specificity to their function to anergize, kill, or protect cognate target cells. CIRs consist of chimeric antigen receptors (CARs) and B-cell antibody receptor (BAR) or chimeric autoantibody receptors (CAARs). Approval of CAR-T cell therapy by the Food and Drug Administration (FDA) has encouraged investigators to search for autoimmune therapies that a...
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#1Magne Børset (NTNU: Norwegian University of Science and Technology)H-Index: 31
#2Anders Sundan (NTNU: Norwegian University of Science and Technology)H-Index: 32
Last. Therese Standal (NTNU: Norwegian University of Science and Technology)H-Index: 16
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Abstract The question of how myeloma cells cause destruction of skeletal tissue has interested scientists for many years, and knowledge in this field has developed in parallel with the understanding of physiological bone remodeling. The identification of bioactive proteins of the cytokine class during the last decades of the previous century and mapping of their role in the regulation of anabolic and catabolic processes in bone, led to a sequence of hypotheses about how the same peptides also co...
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#1Agne Paner (Rush University Medical Center)H-Index: 3
#2Pritesh R. Patel (UIUC: University of Illinois at Urbana–Champaign)H-Index: 6
Last. Binod Dhakal (MCW: Medical College of Wisconsin)H-Index: 9
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Abstract Cytogenetic changes in multiple myeloma (MM) have emerged as one of the most important prognostic factors. Translocations of chromosomes 4 and 14 [t(4;14)], chromosomes 14 and 16 [t(14;16)] and deletion of chromosome 17p [del(17p)] have been incorporated in the Revised International Staging System as a measure of adverse disease biology. Ongoing research is unveiling a complex genomic landscape in MM, with new cytogenetic abnormalities important for prognosis identified and the signific...
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