The Women's Health Initiative trials of menopausal hormone therapy: lessons learned

Objective: The Women's Health Initiative (WHI) assessed oral conjugated equine estrogens (CEE) taken with or without medroxyprogesterone acetate (MPA) for prevention of chronic disease in postmenopausal women aged 50-79 years. Methods: Women with an intact uterus ( n = 16,608) were randomized to CEE+ MPA therapy or placebo for a median of 5.6 years; women with hysterectomy ( n = 10,739) were randomized to CEE-alone therapy or placebo for a...