Chondrogenic differentiation of human bone marrow aspirates enhanced by overexpression of RAAV- SOX9 and TGF-B upon vector delivery via pnass-grafted microstructured poly(E-caprolactone) scaffolds

Purpose: Adult hyaline articular cartilage is an avascular tissue that does not fully regenerate on itself. Gene transfer using the clinically relevant recombinant adeno-associated viral (rAAV) vectors is a powerful tool to enhance cartilage repair [1]. Here, we tested the ability of poly(sodium styrene sulfonate) (pNaSS)-grafted microstructured poly(ε-caprolactone) scaffolds to deliver chondrogenic rAAV sox9 and TFG-β vectors to human bone...