Osteoarthritis and Cartilage
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#1Frank W. Roemer (BU: Boston University)H-Index: 52
#2Jamie E. Collins (Brigham and Women's Hospital)H-Index: 18
Last. Ali Guermazi (BU: Boston University)H-Index: 73
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Summary Purpose Aim was to stratify the knee MRIs of the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium (FNIH) cohort into distinct structural phenotypes based on semiquantitative assessment and to determine risk for pain and structural progression over 48 months. Methods The study sample from the FNIH project was selected as a nested case-control study with knees showing either 1) radiographic and pain progression (i.e., “composite” cases), 2) radiographic pro...
Summary Mitochondrial dysfunction of human articular chondrocytes is considered a hallmark of cartilage degradation and OA pathogenesis. Due to the huge number of cellular processes in which mitochondria is implicated, even in the closed context of cellular respiration, the term mitochondrial function can refer to a variety of features which include fusion and fission, turnover (biogenesis and mitophagy), and plasticity. Mitochondrial biogenesis and mainly mitochondrial fusion and reduced mitoph...
#1Michael C. Nevitt (UCSF: University of California, San Francisco)H-Index: 126
#2David T. Felson (University of Manchester)H-Index: 137
#1April Hartley (UoB: University of Bristol)H-Index: 5
#2S A Hardcastle (UoB: University of Bristol)H-Index: 6
Last. J.S. Gregory (Aberd.: University of Aberdeen)H-Index: 3
view all 13 authors...
Summary Objective High bone mass (HBM) is associated with an increased prevalence of radiographic knee OA (kOA), characterized by osteophytosis. We aimed to determine if progression of radiographic kOA, and its sub-phenotypes, is increased in HBM and whether observed changes are clinically relevant. Design A cohort with and without HBM (L1 and/or total hip bone mineral density Z-score > +3.2) had knee radiographs collected at baseline and 8-year follow-up. Sub-phenotypes were graded using the OA...
#1Langhai XuH-Index: 3
Last. Jisheng RanH-Index: 8
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Summary Objective Metabolic disorders and inflammation of chondrocytes are major pathological changes in aging cells and osteoarthritis (OA). Recent studies demonstrated age-related mitochondrial dysfunction may be a key contributing factor in the development of OA. Mitofusin 2 (MFN2) is a key regulator of mitochondrial fusion, cell metabolism, autophagy and apoptosis. This study was performed to ascertain whether MFN2 was involved in the aging of chondrocytes and OA. Methods Metabolic measureme...
#1Bjørnar Berg (University of Oslo)H-Index: 1
#2Ewa M. Roos (University of Southern Denmark)H-Index: 65
Last. May Arna Risberg (Norwegian School of Sport Sciences)H-Index: 48
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#1Robin Dunn (CMU: Carnegie Mellon University)
#2Joel B. Greenhouse (CMU: Carnegie Mellon University)H-Index: 40
Last. Peter Mesenbrink (Novartis)H-Index: 22
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Summary Objective This study constructs a risk score for patients’ progression to end-stage knee osteoarthritis (OA) within four years. Design The Osteoarthritis Initiative (OAI) was a longitudinal study of the onset and progression of knee OA. Using a recent definition of end-stage knee OA, we implement interval-censored survival forests to select predictors of this endpoint. We fit an interval-censored Cox model for time to end-stage knee OA, using the selected predictors. The risk score is th...
#1Angela T. Chen (Brigham and Women's Hospital)H-Index: 1
#2Swastina Shrestha (Brigham and Women's Hospital)H-Index: 2
Last. Jeffrey N. KatzH-Index: 95
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Summary Objective Conduct a systematic review and use meta-analytic techniques to estimate the proportion of total treatment effect that can be attributable to contextual effects (PCE) in adults receiving nonpharmacological, nonsurgical (NPNS) treatments for knee osteoarthritis (OA). Design We reviewed the published literature to identify five frequently studied NPNS treatments for knee OA: exercise, acupuncture, ultrasound, laser, and transcutaneous electrical nerve stimulation (TENS). We searc...
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