Osteoarthritis and Cartilage
Papers 13840
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#1Dzenita Muratovic (University of Adelaide)H-Index: 3
#2David M. Findlay (University of Adelaide)H-Index: 56
Last.Julia S. Kuliwaba (University of Adelaide)H-Index: 18
view all 7 authors...
Summary Objective The aim of this study was to investigate how bone microstructure within bone marrow lesions (BMLs) relates to the bone and cartilage across the whole human tibial plateau. Design Thirty-two tibial plateaus from patients with osteoarthritis (OA) at total knee arthroplasty and eleven age-matched non-OA controls, were scanned ex vivo by MRI to identify BMLs and by micro CT to quantitate the subchondral (plate and trabecular) bone microstructure. For cartilage evaluation, specimens...
#1Fiona E. Watt (Arthritis Research UK)H-Index: 12
#2Mary Beth Blauwet (CGD: Center for Global Development)H-Index: 11
Last.Nancy E. Lane (UC Davis: University of California, Davis)H-Index: 82
view all 6 authors...
Summary Objective To investigate the TrkA inhibitor, ASP7962, for treatment of painful knee osteoarthritis. Design Phase 2a, double-blind, placebo- and naproxen-controlled, double-dummy, parallel-group study. Adults with knee osteoarthritis were randomized (2:2:1) to ASP7962 (100 mg), placebo, or naproxen (500 mg) twice daily (BID) for 4 weeks. Primary endpoint: change from baseline to Week 4 in Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain subscale score. Secondary endp...
#1Alia M. Obeidat (Rush University Medical Center)H-Index: 1
#2Rachel E. Miller (Rush University Medical Center)H-Index: 18
Last.Anne-Marie Malfait (Rush University Medical Center)H-Index: 33
view all 4 authors...
Summary Objectives To document the nociceptive innervation of the normal and osteoarthritic murine knee. Methods Knees were collected from naive male C57BL/6 NaV1.8-tdTomato reporter mice aged 10, 26, and 52 weeks (n=5/group). Destabilization of the medial meniscus (DMM) or sham surgeries (n=5/group) were performed in the right knee of 10-week old male NaV1.8-tdTomato mice, and knees were harvested 16 weeks later. Twenty 20-μm frozen sections from a 400-μm mid-joint region were collected for con...
#1Xiaohui Zhao (WVU: West Virginia University)H-Index: 2
#2Drishti Shah (WVU: West Virginia University)H-Index: 2
Last.Usha Sambamoorthi (WVU: West Virginia University)H-Index: 32
view all 7 authors...
Summary Objective To estimate the burden of osteoarthritis (OA) among noninstitutionalized adults (≥18 years of age) in the US. Design Weighted nationally representative data from the 2015 Medical Expenditure Panel Survey were used to estimate OA prevalence in noninstitutionalized adults and compare adults with OA to those without OA for clinical (pain interference with activities [PIA], functional limitations), humanistic (health-related quality-of-life [HRQoL]) and economic outcomes (healthcar...
#1Sven Nebelung (RWTH Aachen University)H-Index: 12
#2Manuel Post (RWTH Aachen University)H-Index: 2
Last.Daniel Truhn (RWTH Aachen University)H-Index: 9
view all 9 authors...
Abstract Objective To investigate changes in response to sequential pressure-controlled loading and unloading in human articular cartilage of variable histological degeneration using serial T1ρ mapping. Method We obtained 42 cartilage samples of variable degeneration from the medial femoral condyles of 42 patients undergoing total knee replacement. Samples were placed in a standardized artificial knee joint within an MRI-compatible whole knee-joint compressive loading device and imaged before (δ...
#1Wolfgang WirthH-Index: 34
#2Susanne MaschekH-Index: 13
Last.Felix EcksteinH-Index: 75
view all 6 authors...
Summary Objective To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. Methods 120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite con...
#1Jon Tjörnstrand (Lund University)H-Index: 4
#2Paul Neuman (Lund University)H-Index: 13
Last.Carl Johan Tiderius (Lund University)H-Index: 18
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Summary Objective Rupture of the anterior cruciate ligament (ACL) increases the risk of developing osteoarthritis (OA). Delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) investigates cartilage integrity through T1-analysis after intravenous contrast injection. A high Delayed Gadolinium enhanced MRI of cartilage (dGEMRIC) index represents good cartilage quality. The main purpose of this prospective cohort study was to investigate the prognostic value of the dGEMR...
#1Raveendhara R. Bannuru (Tufts Medical Center)H-Index: 20
#2Mikala C. Osani (Tufts Medical Center)H-Index: 7
Last.Timothy E. McAlindon (Tufts Medical Center)H-Index: 57
view all 21 authors...
Objective: To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular osteoarthritis (OA) that are derived from expert consensus and based on objective review of high-quality meta-analytic data. Methods: We sought evidence for 60 unique interventions. A systematic search of all relevant databases was conducted from inception through July 2018. After abst...
4 CitationsSource
#1Cécile Lambert (University of Liège)H-Index: 11
#2Didier Borderie (Paris V: Paris Descartes University)H-Index: 31
Last.Yves Henrotin (University of Liège)H-Index: 51
view all 5 authors...
Abstract Objective We evaluated the ability of Coll2-1, a type II collagen peptide, to activate pro-inflammatory pathways in synovial cells and to induce arthritis in Lewis rats. Method Human synoviocytes and chondrocytes from knee OA patients were cultured for 24 hours with/without Coll2-1 and/or purified immunoglobulin G (AS0619) binding specifically this peptide, and/or CLI-095, a TLR-4 signaling inhibitor and/or apocynin and diphenyleneiodonium, Reactive oxygen species (ROS) production inhib...
#1Ian J. Wallace (Harvard University)H-Index: 13
Last.Daniel E. Lieberman (Harvard University)H-Index: 3
view all 13 authors...
Summary Objective To investigate whether and how a sedentary lifestyle contributes to knee osteoarthritis (OA) incidence and severity. Design An experiment was conducted using Hartley guinea pigs, an established idiopathic knee OA model. To simulate a sedentary lifestyle, growing animals (n = 18) were housed for 22 weeks in small cages that restricted their mobility, while another group of animals (n = 17) received daily treadmill exercise to simulate moderate physical activity. After the experi...
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