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Osteoarthritis and Cartilage
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Papers 13882
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#1Kevin M.-C. Lee (University of Melbourne)
#2Varun Prasad (University of Melbourne)
Last.Andrew D. Cook (University of Melbourne)H-Index: 32
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Summary OBJECTIVES Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given the clinical data indicating that granulocyte macrophage-colony stimulating factor (GM-CSF) may be a therapeutic target in human OA, we evaluated different treatment regimens with a neutralizing anti-GM-CSF monoclonal antibody (mAb) in an experimental OA model to determine their effectiveness on amelioration of pain and disease. METHODS The collagenase-induced os...
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#1Sarah C. Foreman (TUM: Technische Universität München)H-Index: 3
#2Alexandra S. Gersing (TUM: Technische Universität München)H-Index: 9
Last.Thomas M. Link (UCSF: University of California, San Francisco)H-Index: 77
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Summary Objective To determine if presence of calcium-containing crystals (CaC) is associated with increased knee joint degeneration over four years and assess if total number of CaCs deposited is a useful measure of disease burden. Design Seventy subjects with CaCs in right knees at baseline were selected from the Osteoarthritis Initiative and matched to 70 subjects without evidence of CaCs. T1-weighted gradient-echo sequences were used to confirm presence of CaCs and count the numbers of disti...
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#1Jie Wei (Harvard University)H-Index: 13
#2Malissa J. Wood (Harvard University)H-Index: 29
Last.Yuqing Zhang (Harvard University)H-Index: 80
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ABSTRACT Objective Tramadol has been widely used among patients with osteoarthritis (OA); however, there is paucity of information on its cardiovascular risk. We aimed to examine the association of tramadol with risk of myocardial infarction (MI) among patients with OA. Design Among OA patients aged 50 to 90 years without history of MI, cancer, or opioid use disorder in The Health Improvement Network database in the United Kingdom (2000-2016), three sequential propensity-score matched cohort stu...
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#1Delaram Shakoor (Johns Hopkins University)H-Index: 3
#2Shadpour Demehri (Johns Hopkins University)H-Index: 14
Last.Ali Guermazi (BU: Boston University)H-Index: 73
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Summary Objective To determine the correlation between knee synovitis assessed on contrast-enhanced (CE) and non-contrast enhanced (NCE) magnetic resonance imaging (MRI) with histology in patients with knee osteoarthritis. Methods A comprehensive literature search was performed, and related articles published through July 2018 were extracted. Spearman correlation coefficients of MRI-based scores with histology reports were pooled using random effects model. To evaluate presence of publication bi...
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#1S. Malek (Purdue University)
#2H. Sun (Purdue University)
Last.Christopher B. Riley (Massey University)H-Index: 12
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Summary Objective To evaluate infrared (IR) spectroscopy of serum as a screening tool to differentiate dogs affected by naturally occurring osteoarthritis (OA) associated with cranial cruciate ligament rupture (CrCLR) and controls. Method 104 adult dogs with CrCLR (affected group) and 50 adult control dogs were recruited for this prospective observational study. Serum samples were collected preoperatively from CrCLR dogs and from a subset of these dogs at 4-, and 12-week post-surgical interventi...
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#1Kehinde Akin-Akinyosoye (Arthritis Research UK)H-Index: 2
#2Aliya Sarmanova (Arthritis Research UK)H-Index: 4
Last.David A. Walsh (Arthritis Research UK)H-Index: 49
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Summary OBJECTIVES We investigated whether baseline scores for a self-report trait linked to central mechanisms predict 1 year pain outcomes in the Knee Pain In the Community cohort. METHOD 1471 participants reported knee pain at baseline and responded to a 1-year follow-up questionnaire, of whom 204 underwent pressure pain detection thresholds (PPTs) and radiographic assessment at baseline. Logistic and linear regression models estimated the relative risks (RRs) and associations (β) between sel...
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#1Sebastian Apprich (Medical University of Vienna)H-Index: 15
#2Markus M. Schreiner (Medical University of Vienna)H-Index: 5
Last.Siegried Trattnig (Medical University of Vienna)
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Summary Objective The objective was to demonstrate the potential of axial T2 mapping for quantification of untreated early-stage patellar cartilage lesions over time and to assess its capability as a potential predictive marker for future progression. Study Design & Methods Thirty patients (mean age, 36.7 ± 11.1 years; 16 males), with early-stage patellar cartilage defects (≤ICRS grade 2) at baseline and no treatment during follow up (4.0± 1.6 years) were enrolled. Morphological cartilage change...
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#1Peter C. Gray (UCSD: University of California, San Diego)
#2Senyon Choe (UCSD: University of California, San Diego)H-Index: 48
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#1Toshiko Iidaka (UTokyo: University of Tokyo)H-Index: 4
#2Shigeyuki Muraki (UTokyo: University of Tokyo)H-Index: 27
Last.Noriko Yoshimura (UTokyo: University of Tokyo)H-Index: 44
view all 9 authors...
Abstract Objective To investigate the incidence and progression rate of radiographic hip osteoarthritis (OA) and its risk factors in Japanese men and women using a large-scale population of a nationwide cohort study, Research on Osteoarthritis/osteoporosis Against Disability (ROAD). Methods From the baseline survey of the ROAD study, 2,975 participants (1,043 men and 1,932 women) aged 23 to 94 years (mean, 70.2 years) living in urban, mountainous, and coastal communities were followed up with hi...
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#1Marieke Loef (LUMC: Leiden University Medical Center)H-Index: 3
#2Andreea Ioan-Facsinay (LUMC: Leiden University Medical Center)H-Index: 31
Last.Frits R. Rosendaal (LUMC: Leiden University Medical Center)H-Index: 118
view all 7 authors...
Abstract Objective To investigate the association of postprandial and fasting plasma saturated fatty acid (SFAs), monounsaturated fatty acid (MUFAs) and polyunsaturated fatty acid (PUFAs) concentrations with hand and knee osteoarthritis (OA). Design In the population-based NEO study clinical hand and knee OA were defined by the ACR classification criteria. Structural knee OA was defined on MRI. Hand and knee pain was determined by AUSCAN and KOOS, respectively. Plasma was sampled fasted and 150 ...
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Top fields of study
Anatomy
Physical therapy
Osteoarthritis
Cartilage
Medicine