Enzymatic deinduction phenomenon and clinical implications with a focus on direct-acting oral anticoagulants

The aim of the study was to describe the deinduction process and clinically relevant cases reported in the medical literature. Performed PubMed database search for key words ‘enzymatic deinduction’. Findings are summarized. Although many unwanted drug interactions occur from the additive effects of combined medications or through competition at binding sites, some interactions occur because of alterations in homeostasis of natural metabolizing...