The Renal Physiology of Pendrin-Positive Intercalated Cells

Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the three IC subtypes identified, type B intercalated cells are one of the best characterized and known to mediate Cl − absorption and HCO 3 − secretion, largely through the anion exchanger pendrin. This exchanger is thought to act in tandem with the Na + -dependent Cl − /HCO 3 − exchanger, NDCBE, to mediate net NaCl absorption. Pendrin is stimulated by...